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EC number: 423-740-1 | CAS number: 10461-98-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
From experimental study it is concluded that the test substance 2-cyclohexylidene-2-phenylacetonitrile non irritating to skin and eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from test report
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EEC
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- No details available
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- other: The undiluted test material was used
- Controls:
- not specified
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 4 h
- Observation period:
- No data
- Number of animals:
- 3
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Remarks on result:
- other: mean score 1
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Remarks on result:
- other: mean score 2
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Remarks on result:
- other: mean score 3
- Irritation parameter:
- erythema score
- Remarks on result:
- other: Max. duration: d; Max. value at end of observation period: 0 (related to all animals)
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Remarks on result:
- other: other details not available
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Remarks on result:
- other: other details not available
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Remarks on result:
- other: other details not available
- Irritation parameter:
- edema score
- Remarks on result:
- other: Max. duration: d; Max. value at end of observation period: 0 (related to all animals)
- Other effects:
- No signs of irritation were noted at any time.
- Interpretation of results:
- not irritating
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- In skin irritation study erythema and edema score observed for overall at 24, 48 and 72 h in 3 New Zealand White rabbits at dose concentration of 500 mg resulted score .Thus it can be concluded that the test substance 2-cyclohexylidene-2-phenylacetonitrile is non irritating to skin.
- Executive summary:
In skin irritation study erythema and edema score observed for overall at 24, 48 and 72 h in 3 New Zealand White rabbits at dose concentration of 500 mg resulted score .Thus it can be concluded that the test substance 2-cyclohexylidene-2-phenylacetonitrile is non irritating to skin.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from test report
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EEC
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 0.1 ML
- Duration of treatment / exposure:
- No data
- Observation period (in vivo):
- No data
- Number of animals or in vitro replicates:
- 3
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #1
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Remarks on result:
- other: mean score 1
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #2
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 1
- Remarks on result:
- other: mean score 2
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #3
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Remarks on result:
- other: mean score 3
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Score:
- 1
- Remarks on result:
- other: Max. duration: 24 h; Max. value at end of observation period: 0 (related to all animals)
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Remarks on result:
- other: mean score 1
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Remarks on result:
- other: mean score 2
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Remarks on result:
- other: mean score 3
- Irritation parameter:
- chemosis score
- Score:
- 0
- Remarks on result:
- other: Max. duration: h; Max. value at end of observation period: 0 (related to all animals)
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Remarks on result:
- other: mean score 1
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Remarks on result:
- other: mean score 2
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Remarks on result:
- other: mean score 3
- Irritation parameter:
- cornea opacity score
- Score:
- 0
- Remarks on result:
- other: Max. duration: h; Max. value at end of observation period: 0 (related to all animals)
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Remarks on result:
- other: mean score 1
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Remarks on result:
- other: mean score 2
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Remarks on result:
- other: mean score 3
- Irritation parameter:
- iris score
- Score:
- 0
- Remarks on result:
- other: Max. duration: h; Max. value at end of observation period: 0 (related to all animals)
- Irritant / corrosive response data:
- Reversibility of any observed effect: Changes fully reversible within 1 days
- Other effects:
- Moderate watery discharge from the eyes of all rabbits was noted at one hour only. Two rabbits showed slight reddening of the conjunctiva at one hour.
- Interpretation of results:
- not irritating
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- Test substance 2-cyclohexylidene-2-phenylacetonitrile was not irritating to rabbit eyes.
- Executive summary:
In eye irritation experimental study on 3 New Zeland white rabbit at dose concentration of 0.1 ml applied and observed for 24, 48 and 72 hrs respectively.
In study conjunctivae (redness), chemosis , cornea , iris score become 0.This scoring system indicate that the test substance 2-cyclohexylidene-2-phenylacetonitrile is non irritating to eye.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation / corrosion:
In skin irritation study erythema and edema score observed for overall at 24, 48 and 72 h in 3 New Zealand White rabbits at dose concentration of 500 mg resulted score .Thus it can be concluded that the test substance 2-cyclohexylidene-2-phenylacetonitrile is non irritating to skin.
Eye irritation:
In eye irritation experimental study on 3 New Zeland white rabbit at dose concentration of 0.1 ml applied and observed for 24, 48 and 72 hrs respectively.
In study conjunctivae (redness), chemosis , cornea , iris score become 0.This scoring system indicate that the test substance 2-cyclohexylidene-2-phenylacetonitrile is non irritating to eye.
Justification for selection of skin irritation / corrosion endpoint:
In skin irritation study erythema and edema score observed for overall at 24, 48 and 72 h in 3 New Zealand White rabbits at dose concentration of 500 mg resulted score .Thus it can be concluded that the test substance 2-cyclohexylidene-2-phenylacetonitrile is non irritating to skin.
Justification for selection of eye irritation endpoint:
In eye irritation experimental study on 3 New Zeland white rabbit at dose concentration of 0.1 ml applied and observed for 24, 48 and 72 hrs respectively.
In study conjunctivae (redness), chemosis , cornea , iris score become 0.This scoring system indicate that the test substance 2-cyclohexylidene-2-phenylacetonitrile is non irritating to eye.
Justification for classification or non-classification
On the basis of available experimental data, the substance 2-cyclohexylidene-2-phenylacetonitrile is consider to be non irritating to skin and eye. It is thus not consider for further classification as per CLP criteria.
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