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Diss Factsheets
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EC number: 943-428-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given (no data on test substance purity).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 951
- Report date:
- 1951
Materials and methods
- Objective of study:
- other: hydrolysis
- Principles of method if other than guideline:
- The purpose of the study was to determine the hydrolysis of different sorbitan esters by lipase in vitro.
- GLP compliance:
- no
Test material
- Reference substance name:
- Sorbitan stearate
- EC Number:
- 215-664-9
- EC Name:
- Sorbitan stearate
- Cas Number:
- 1338-41-6
- IUPAC Name:
- 1,4-anhydro-6-O-stearoyl-D-glucitol
- Details on test material:
- - Name of test material (as cited in study report): sorbitan monostearate, span 60
- Analytical purity: no data
Constituent 1
- Radiolabelling:
- no
Administration / exposure
- Route of administration:
- other: in vitro application
- Vehicle:
- unchanged (no vehicle)
- Duration and frequency of treatment / exposure:
- 24 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2 mL
- Positive control reference chemical:
- corn oil (2 mL) and control runs (enzyme free)
- Details on study design:
- After preliminary trial runs the following type of mixture was subjected to the digestive influence of pancreatic lipase: 2 mL test substance, 50 mg bile salts, pancreatin, U.S.P. 200 mg and 15 mL water. The mixture was rendered slightly alkaline to phenolphtalein by the addition of N/20 sodium hydroxide and placed in an incubator for 24 hours at 37°C. Two experiments in each group were run. After the incubation period the free fatty acid liberated was titrated with N/20 sodium hydroxide, after the addition of 15 mL alcohol, using phenolphthalein soution as the indicator.
Results and discussion
Any other information on results incl. tables
Table 1: Free fatty acid content after in vitro hydrolysis of the test substance by lipase
|
mL N/20 NaOH |
Weight of ester |
Weight of fatty acid (g) |
% fatty acid |
Liberated fatty acid (g) |
% fatty acid present in ester liberated |
Corn oil |
29.6 |
2 |
1.92 |
96.1 |
0.41 |
21.4 |
Test compound |
5.7 |
2 |
1.48 |
74 |
0.08 |
5.4 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.