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EC number: 200-665-9 | CAS number: 67-71-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Data is from peer-reviewed journal.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Toxicity of the given substance in rats
- Author:
- Horvath et al.
- Year:
- 2 002
- Bibliographic source:
- Food and Chemical Toxicology
- Reference Type:
- other: secondary database
- Title:
- Report on the test chemical
- Author:
- Food and Drug Administration
- Year:
- 2 007
- Bibliographic source:
- Food and Drug Administration
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity of the substance was assessed in Sprague-dawley rats.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Dimethyl sulphone
- EC Number:
- 200-665-9
- EC Name:
- Dimethyl sulphone
- Cas Number:
- 67-71-0
- Molecular formula:
- C2H6O2S
- IUPAC Name:
- dimethyl sulphone
- Details on test material:
- - IUPAC Name: Dimethyl sulphone
- InChI: 1S/C2H6O2S/c1-5(2,3)4/h1-2H3
- Smiles: S(C)(C)(=O)=O
- Molecular formula:C2H6O2S
- Molecular weight:94.1334 g/mole
- Substance type:Organic
- Physical state:Solid
SOURCE OF TEST MATERIAL
- Source of test material: Cardinal Nutrition (Cardinal OptiMSMTM, Vancouver, WA, USA
- Lot/batch No.of test material: 98019
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories (Raleigh, NC, USA).
- Age at study initiation: 6 weeks old
- Weight at study initiation: 206–220 g (males), 146–165 g (females)
- Housing: housed individually in solid-bottomed polycarbonate cages lined with heat-treated hardwood chip bedding
- Diet (e.g. ad libitum): Certified Rodent Diet #5002
- Water (e.g. ad libitum): tap water public
water supply
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): between 69 and 750 °F
- Humidity (%): between 37 and 60%.
- Photoperiod (hrs dark / hrs light): 12-h light/dark cycle.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- sterile water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2g/kg
MAXIMUM DOSE VOLUME APPLIED: 10ml/kg - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 10 male and 10 female rats
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were checked for clinical signs and mortality twice a day. Each rat was weighed on days 1, 5, 8, 12 and 15.
- Necropsy of survivors performed: yes, rats were sacrificed on day 15 by CO2 asphyxiation.
Necropsy examinations included a thorough inspection of all external surfaces, organs and orifices. The following organs and tissues were examined: adrenals, aorta, brain, cecum, colon, duodenum, epididymides, esophagus, eyes, heart, ileum, jejunum, kidneys, larynx, liver, lungs, lymph nodes (mesenteric, mandibular), mammary glands, ovaries, pancreas, parathyroid, prostate, rectum, salivary glands, skeletal muscle, skin, spleen, stomach (fundic area), testes, thyroid, tongue, trachea, urinary bladder, uterus and vagina. - Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality observed
- Mortality:
- No mortality was observed at the dose concentration of 2000 mg/kg bw.
- Clinical signs:
- other: No adverse effects or clinical signs of toxicity were observed for any animals dosed during the study.
- Gross pathology:
- No gross lesions were noted in any rats on necropsy.
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute oral LD50 value was considered to be >2000 mg/kg bw, when 10 male and 10 female Sprague-dawley rats were treated with the given test chemical via oral gavage route.
- Executive summary:
The acute oral toxicity study was conducted by using the given test chemical in when 10 male and 10 female Sprague-dawley rats at the dose concentration of 0 and 2000 mg/kg bw.
The given test chemical was dissolved in sterile water and administered as 10 ml/kg via oral gavage route. The control animals received sterile water only.
Animals were checked for clinical signs and mortality twice a day. Each rat was weighed on days 1, 5, 8, 12 and 15. Necropsy of survivors performed. Rats were sacrificed on day 15 by CO2 asphyxiation. Necropsy examinations included a thorough inspection of all external surfaces, organs and orifices. The following organs and tissues were examined: adrenals, aorta, brain, cecum, colon, duodenum, epididymides, esophagus, eyes, heart, ileum, jejunum, kidneys, larynx, liver, lungs, lymph nodes (mesenteric, mandibular), mammary glands, ovaries, pancreas, parathyroid, prostate, rectum, salivary glands, skeletal muscle, skin, spleen, stomach (fundic area), testes, thyroid, tongue, trachea, urinary bladder, uterus and vagina.
No mortality was observed at the dose concentration of 2000 mg/kg bw. No adverse effects or clinical signs of toxicity were observed for any animals dosed during the study. No discernible differences in weight gain were noted between treatment groups. No gross lesions were noted in any rats on necropsy.
Under the condition of the study, the LD50 value was considered to be >2000 mg/kg bw, when 10 male and 10 female Sprague-dawley rats were treated with the given test chemical via oral gavage route.
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