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Diss Factsheets
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EC number: 208-523-8 | CAS number: 532-02-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Final Report on the Amended Safety Assessment of Sodium Polynaphthalene sulfonate and Sodium Naphthalenesulfonate
- Author:
- Cosmetic Ingredient Review Expert Panel
- Year:
- 2 003
- Bibliographic source:
- International Journal of Toxicology, 22(Suppl. 2):37–44, 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- To evaluate the toxicity of Sodium naphthalene-beta-sulfonate in white rabbits by dermal application.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium naphthalene-2-sulphonate
- EC Number:
- 208-523-8
- EC Name:
- Sodium naphthalene-2-sulphonate
- Cas Number:
- 532-02-5
- Molecular formula:
- C10H8O3S.Na
- IUPAC Name:
- sodium naphthalene-2-sulphonate
- Reference substance name:
- Sodium 2-naphthalenesulfonate
- IUPAC Name:
- Sodium 2-naphthalenesulfonate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): SNS (sodium 2-naphthalenesulfonate)
- Molecular formula (if other than submission substance): C10H8O3S.Na
- Molecular weight (if other than submission substance): 230.23 g/mol
- Substance type: Organic
- Physical state: No data available
Purity
- Impurities (identity and concentrations): Not more than 0.5% sulfate (as sodium sulfate); not more than 20 mg/kg of heavy metals; and not more than 2 mg/kg arsenic.
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- other: Japanese albino rabbits
- Details on test animals or test system and environmental conditions:
- Sex: Female
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: abraded and intact
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- Amount-0.5 g
Concentration applied-100% (undiluated) - Duration of treatment / exposure:
- 24 hour
- Observation period:
- 3, 24, and 48 h
- Number of animals:
- Three
- Details on study design:
- TEST SITE
- Area of exposure: The test material was applied to abraded and intact skin at clipped sites on the animals’ backs.
- % coverage: 100%
- Type of wrap if used: Closed patch.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): No data available.
- Time after start of exposure:
CONTROL ANIMALS:
One abraded and one intact site received petroleum jelly.
SCORING SYSTEM: Reactions were scored for erythema and eschar formation on a scale of 0 to 4, and for edema on the same scale. A total score in the range of ≥5 to 8 was considered severely irritating; ≥2 to <5 was moderately irritating; >0 to <2 was mildly irritating; and a score of 0 was considered not irritating.
Results and discussion
In vivo
Results
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 3 hr
- Score:
- 1
- Max. score:
- 8
- Reversibility:
- no data
- Remarks on result:
- other: Mild irritant
- Irritant / corrosive response data:
- In only one animal, at the 3-h reading, was a grade 1 erythema seen with the undiluted material. No positive Erythema or edema scores were seen with the other animals exposed to undiluted SNS.
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Sodium 2-naphthalenesulfonate was found to be mild irritant to rabbit skin when applied undiluted.
- Executive summary:
In skin irritation study three female Japanese albinorabbitswere observed forSodium 2-naphthalenesulfonate toxicity. The test material was applied undiluted (0.5 g) to abraded and intact skin at clipped sites on the animals’ backs and a closed patch applied. After 24 h, the closed patch was removed, and the skin reactions were scored at 3, 24, and 48 h thereafter. In only one animal, at the 3-h reading, was a grade 1 erythema seen with the undiluted material. No positive Erythema or edema scores were seen with the other animals exposed to undiluted SNS. The authors concluded that SNS may be considered a mild irritant when applied undiluted.
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