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Diss Factsheets
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EC number: 443-400-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1 December 1997 - 26 December 1998
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study was performed in a GLP laboratory but was not conducted in accordance with an OECD or EU test guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.1175 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 443-400-4
- EC Name:
- -
- Cas Number:
- 181696-73-1
- Molecular formula:
- C16H15NO2
- IUPAC Name:
- 4,5-Dihydro-5-methyl-3,4-diphenyl-5-isoxazolol
- Test material form:
- other: White solid
- Details on test material:
- - Name of test material (as cited in study report): SC-66285
- Physical state: White solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD®(SD)BR.
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories Inc. Portage, Michigan on 3 and 17 November 1997.
- Age at study initiation: Young adult
- Weight at study initiation: 200 - 300 g
- Fasting period before study: 17 to 20 hours
- Housing: suspended, stainless steel cages
- Diet (e.g. ad libitum): Rodent Diet #8604 (Harlan Teklad)
- Water (e.g. ad libitum): yes
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 - 26°C
- Humidity (%): 50% ± 20%
- Photoperiod (hrs dark / hrs light): 12-hour light/12-hour dark cycle
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- variable ( 5,000 mg/kg of body weight)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 0.25 g/mL
- Amount of vehicle (if gavage): 20 mL/kg - Doses:
- 5,000 mg/kg of body weight.
- No. of animals per sex per dose:
- 5 males and 5 females for the initial dose level
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 1, 2.5 and 4 hours after initial administration and daily thereafter.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights and necropsy were measured and/or performed.
Results and discussion
- Preliminary study:
- No mortality was observed during the study. The estimated oral LD5o values for male and female rats were determined to be greater than 5,000 mg/kg of body weight.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- None.
- Clinical signs:
- other: None.
- Gross pathology:
- None.
Applicant's summary and conclusion
- Interpretation of results:
- other: The estimated oral LD50 values for male and female rats were determined to be greater than 5,000 mg/kg.
- Remarks:
- Criteria used for interpretation of results: not specified
- Conclusions:
- In conclusion, a single oral dose of SC-66285 by oral gavage did not cause clinical signs or mortality. The estimated oral LD50 values for male and female rats were determined to be greater than 5,000 mg/kg.
- Executive summary:
The acute oral lethality potential of SC-66285 was evaluated in five male and five female rats. A single oral dose of SC-66285 by oral gavage did not cause clinical signs or mortality. The estimated oral LD50 values for male and female rats were determined to be greater than 5,000 mg/kg.
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