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EC number: 233-546-5 | CAS number: 10226-30-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: data from publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Cycloalkanones. 7. Hypocholesterolemic Activity of Aliphatic Compounds Related to 2,8-Dibenzylcyclooctanone
- Author:
- G. L. Carlson,I. H. Hall, and C. Piantadosi
- Year:
- 1 975
- Bibliographic source:
- Journal of Medicinal Chemistry, 1975, Vol. 18, No. 10 pp 1024-1026
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as per mentioned below
- Principles of method if other than guideline:
- The developmental toxicity test has been conducted on chemical 2-octanone,exposed to male CF1 mice intraperitonialy daily with dose concentration of 50mg/kg/day.
- GLP compliance:
- no
Test material
- Reference substance name:
- Octan-2-one
- EC Number:
- 203-837-1
- EC Name:
- Octan-2-one
- Cas Number:
- 111-13-7
- IUPAC Name:
- octan-2-one
- Details on test material:
- - Name of test material: Octan-2-one
- Molecular formula: C8H16O
- Molecular weight: 128.21 g/mol
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CF-1
- Details on test animals or test system and environmental conditions:
- Details on test animal & Environmental conditions
TEST ANIMALS
- Source: Carworth Farms
- Age at study initiation: No data available
- Weight at study initiation: No data available
- Fasting period before study: No data available
- Housing: No data available
- Diet (e.g. ad libitum): Purina lab chow
- Water (e.g. ad libitum): ad libitum - Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%):No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available
IN-LIFE DATES: From: To:
Administration / exposure
- Route of administration:
- other: Intraperitonial
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- other: carboxymethylcellulose- H20(CMC)
- Details on exposure:
- Details on exposure
PREPARATION OF DOSING SOLUTIONS:
Test compound was suspended in 1% carboxymethylcellulose- H20 (1% CMC) and homogenized. Doses (mg/kg) were calculated on daily weights of the mice
VEHICLE
- Justification for use and choice of vehicle (if other than water):No data available
- Concentration in vehicle:50 mg/kg/day
- Amount of vehicle (if gavage):1% - Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- No data available
- Details on mating procedure:
- No data available
- Duration of treatment / exposure:
- No data available
- Frequency of treatment:
- Daily
- Duration of test:
- 19.4 days- average gestation time
- No. of animals per sex per dose:
- No data available
- Control animals:
- yes
- Details on study design:
- Control animals were given 1% CMC only
Examinations
- Maternal examinations:
- Antifertility activity
- Ovaries and uterine content:
- No data available
- Fetal examinations:
- Yes,Average number of fetuses per litter
- Statistics:
- the number of animals in a group, expressed as N, the mean of the percent of control, and standard deviation, expressed as i f S.D.,ar e noted. The probable
significant level ( p ) was determined by the Student's t test according to the procedure of Snedecor. - Indices:
- No data available
- Historical control data:
- No data available
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Maternal toxic effects:no effects. Remark: no antifertility was observed at an effective dose level.
Effect levels (maternal animals)
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- 50 mg/kg bw/day
- Based on:
- test mat.
- Basis for effect level:
- other: developmental toxicity
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:yes. Remark: Average no. of fetuses per litter – no significant change was observed as compared to control.
Effect levels (fetuses)
- Key result
- Remarks on result:
- not measured/tested
Fetal abnormalities
- Key result
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The no observed adverse effect level was found to be 50 mg/kg/day when exposed to female mice intraperitonially by chemical 2-octanone daily for 19.4(gestation days) days.
- Executive summary:
The developmental toxicity test has been conducted on chemical 2-octanone,exposed to male CF1 mice intraperitonialy daily with dose concentration of 50mg/kg/day.the number of viable fetuses per litter was observed in the test.No significant change was observed as compared to control.Hence, The no observed adverse effect level was found to be 50 mg/kg/day when exposed to female mice intraperitonially by chemical 2-octanone daily for 19.4(gestation days) days..
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