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EC number: 203-266-8 | CAS number: 105-06-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database.
Data source
Referenceopen allclose all
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity by using test chemical
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- ChemIDplus
- Reference Type:
- secondary source
- Title:
- Toxicity Study
- Author:
- NTRL
- Year:
- 1 990
- Bibliographic source:
- NTRL
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity of test chemical in rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 4-Ethenylphenyl acetate
- EC Number:
- 607-905-5
- Cas Number:
- 2628-16-2
- Molecular formula:
- C10H10O2
- IUPAC Name:
- 4-Ethenylphenyl acetate
- Details on test material:
- - IUPAC Name: 4-Ethenylphenyl acetate- InChI: 1S/C10H10O2/c1-3-9-4-6-10(7-5-9)12-8(2)11/h3-7H,1H2,2H3- Smiles: O=C(Oc1ccc(cc1)C=C)C- Molecular formula:C10H10O2- Molecular weight :162.187 g/mole- Substance type:Organic- Physical state:Liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CD rat
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Age at study initiation: 4 week-old- Fasting period before study: fasted overnight
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- not specified
- Doses:
- 700, 1000, 1429, 2014 mg/kg
- No. of animals per sex per dose:
- groups of 5 rats of each sex
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days - Necropsy of survivors performed: yes, survivors were killed and necropsied.- Other examinations performed: Animals were observed for mortality and clinical signs.
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 732 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 503 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 027 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Mortality occurred within 3 days of administration.
- Clinical signs:
- Clinical signs at dose levels of 1000 mg/kg and above were severe but did not suggest any specific mechanism of toxicity.
- Body weight:
- not specified
- Gross pathology:
- Necropsy of decedents revealed altered stomach contents and occasionally dark thymus, dark areas on the gastric mucosa and body surface staining.
- Other findings:
- not specified
Any other information on results incl. tables
Table
DOSAGE mg/kg | MORTALITY | COMMENTS | |
Males | Females | ||
700 | 0/5 | 0/5 | Minimal Effects |
1000 | 1/5 | 0/5 | Survivors appeared normal after day 5 |
1429 | 2/5 | 2/5 |
|
2014 | 4/5 | 2/5 | Cause of death not determined |
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Acute oral toxicity dose (LD50) value was considered to be 1732 mg/kg in both male and female; 1503 mg/kg in males; and 2027 mg/kg in females, when groups of 5 CD rats of each sex were treated with test chemical via oral gavage route.
- Executive summary:
Acute oral toxicity study was conducted by using test chemical in groups of 5 CD rats of each sex at the dose concentration of 700, 1000, 1429, 2014 mg/kg bw. The test chemical was dissolved incorn oil and administered via oral gavage route. Animals were observed for mortality and clinical signs for 14 days after administration of the test substance and survivors were killed and necropsied. Decedents were necropsied as soon as possible after death. Mortality occurred within 3 days of administration. Clinical signs at dose levels of 1000 mg/kg and above were severe but did not suggest any specific mechanism of toxicity. Necropsy of decedents revealed altered stomach contents and occasionally dark thymus, dark areas on the gastric mucosa and body surface staining. Hence, LD50 value was considered to be 1732 mg/kg in both male and female; 1503 mg/kg in males; and 2027 mg/kg in females, when groups of 5 CD rats of each sex were treated with test chemical via oral gavage route.
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