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EC number: 233-059-8 | CAS number: 10026-12-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
For the conducted semi-static acute immobilization test with Daphnia magna, applying nominal concentrations of 889 to 4500 mg/L niobium pentachloride, nominal effect levels were calculated:
- 48 h EL50 (nominal): 1498 mg/L (95%-CI: 1286 – 1723 mg/L);
- 48h LOELR: 1333 mg/L;
- 48h NOELR: 889 mg/L.
Due to methodological difficulties, it was not possible to calculate effect concentrations based on measured concentrations. Hence, values are reported based on the nominal loading rates.
Key value for chemical safety assessment
Additional information
The 48-h acute toxicity of niobium pentachloride to Daphnia magna was studied under the conditions of OECD guideline 202 (semi-static conditions). Daphnids were exposed to a control containing no test substance and niobium pentachloride at nominal loading rates of 889, 1333, 2000, 3000 and 4500 mg/L for 48 h. Immobilization was observed daily. Due to highly variable Nb5+ concentrations in solution, effect concentrations were based on nominal loading rates.The 48-hour EL50 was 1498 mg/L. The 48-h NOELR based on immobilization was 889 mg/L and the LOELR was 1333 mg/L.This study is classified as acceptable and satisfies the guideline requirements for an acute toxicity study with freshwater invertebrates. However, it was not possible to determine effect levels based on measured effective test substance concentrations. After pH adjustment the measured Nb5+ concentrations were low and showed high variability. Therefore, no concentration-response relationship could be established. Concentrations of the test sample varied due to precipitation, agglomeration and adsorption reactions. In addition, slight changes in pH had profound impact on the test concentrations. Observed immobilization effects may therefore rather predominantly refer to elevated NaCl concentrations, originated from neutralization, than released Nb5+ ions. Reported EC50 values for sodium chloride vary but may be as low as 874 mg/L (ECHA registry for sodium chloride). Due to a concentration of approximately 4.68 g/L NaCl, present at the highest loading rate of 4500 mg/L test substance, and the sensitivity of D.magna to salinity, any hypothetical Nb5+ related effects cannot be distinguished from NaCl induced inhibition in the conducted test.
This study is classified as acceptable and satisfies the guideline requirements for an acute toxicity study with freshwater invertebrates.
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