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EC number: 281-506-0 | CAS number: 83968-28-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Acute eye irritation/corrosion study of CALCOZINE ~ black CSP powder in New Zealand white rabbits
- Author:
- NTRL
- Year:
- 1 985
- Bibliographic source:
- NTIS/ OTS0539527
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD guideline
- Principles of method if other than guideline:
- To evaluate the potential for ocular irritation of the test article C.I. Basic Violet 1 when administered to New Zealand white rabbits.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- C.I. Basic Violet 1
- IUPAC Name:
- C.I. Basic Violet 1
- Reference substance name:
- 8004-87-3
- EC Number:
- 616-846-4
- Cas Number:
- 8004-87-3
- Molecular formula:
- C24H28ClN3
- IUPAC Name:
- 8004-87-3
- Test material form:
- other: DYE
- Details on test material:
- - Name of test material (as cited in study report): C.I. Basic Violet 1
- Molecular formula: C24H28ClN3
- Molecular: 393.95 g/mol
- Substance type: Organic
-OTHER- The enclosed study provides information on a commercial mixture.The mixture contains 21 % of C.I. Basic Violet 1 in a commercial mixture of CALCOZINE black CSP powder.
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Sgarlat"s Rabbitry, Harveys Lake
- Age at study initiation: Adult
- Weight at study initiation: 2.28 -2.77 kg
- Fasting period before study: No data available.
- Housing: The rabbits were individually housed in wire mesh bottom cages.
- Diet (e.g. ad libitum): NIH 09 Rabbit Ration (Zeigler Brothers, Gardners, PA) ad libitum
- Water (e.g. ad libitum): water ad libitum.
- Acclimation period: 5 days
Or Test Tissue- Not applicable.
- Source:
- Type:
- Acclimation :
- Housing conditions:
ENVIRONMENTAL CONDITIONS
- Temperature (°C):
- Humidity (%):
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light): 12 hour dark /12 hrs light
Test system
- Vehicle:
- not specified
- Controls:
- other: the other eye serves as control.
- Amount / concentration applied:
- 0.1 g
- Duration of treatment / exposure:
- 1,24,48 and 4th day
- Observation period (in vivo):
- 30 seconds
- Number of animals or in vitro replicates:
- 9 animals
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): 3 rabbits' eyes were irrigated
with lukewarm tap water
- Time after start of exposure: 30-seconds after instillation for approximately one minute.
SCORING SYSTEM: Draize Scale for Scoring Ocular Lesions.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1,24,48 hours and 4day
- Reversibility:
- not reversible
- Remarks on result:
- other: Severe Irritation was observed before and after washing of eyes.
Applicant's summary and conclusion
- Interpretation of results:
- other: Severe Irritation
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Basic Violet 1 eye irritation test result for New Zealand white rabbits was observed. Basic Violet 1 was observed as severe irritating substance.
- Executive summary:
Eye irritation effect ofBasic Violet 1 was observed in NewZealand white rabbits. 9NewZealand white rabbits were taken for the test. An amount of 0.1 g of the test article was instilled into one eye of each rabbit and other eye served as control. The treated eyes of six animals remained unwashed and three rabbits' eyes were irrigated with lukewarm tap water 30-seconds after instillation for approximately one minute. The grade of ocular reaction for each animal recorded at 1, 24. 48 and 72 hours and at 4thday post instillation using the Draize Scale for Scoring Ocular Lesions. In six rabbits Eyes were not irrigated after test article instillation. While in 3 rabbits Eyes were irrigated 30seconds after test article instillation. Severe irritations were observed in all 9 rabbit before and after washing of eyes. Therefore it can be concluded that the test substance Basic Violet 1 was observed to be severe irritating in New Zealand white rabbits. Hence this substance can be classified as eye irritant.
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