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EC number: 258-964-5 | CAS number: 54079-53-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Justification for type of information:
- data is from experimental reports
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the dermal irritation potential of the test chemical in New Zealand White rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- [[4-[[2-(4-cyclohexylphenoxy)ethyl]ethylamino]-2-methylphenyl]methylene]malononitrile
- EC Number:
- 258-964-5
- EC Name:
- [[4-[[2-(4-cyclohexylphenoxy)ethyl]ethylamino]-2-methylphenyl]methylene]malononitrile
- Cas Number:
- 54079-53-7
- Molecular formula:
- C27H31N3O
- IUPAC Name:
- 2-[(4-{[2-(4-cyclohexylphenoxy)ethyl](ethyl)amino}-2-methylphenyl)methylidene]propanedinitrile
- Test material form:
- solid
- Details on test material:
- - Name of test material : Macrolex Yellow 6G
- IUPAC name : (4-{[2-(4-cyclohexylphenoxy)ethyl](ethyl)amino}-2-methylbenzylidene)malononitrile / Solvent Yellow 179
- Molecular formula): C27H31N3O
- Molecular weight :413.562 g/mol
- Smiles notation : N#C\C(C#N)=C/c1c(cc(N(CCOc2ccc(cc2)C2CCCCC2)CC)cc1)C
- InChl: 1S/C27H31N3O/c1-3-30(26-12-9-25(21(2)17-26)18-22(19-28)20-29)15-16-31-27-13-10-24(11-14-27)23-7-5-4-6-8-23/h9-14,17-18,23H,3-8,15-16H2,1-2H3
- Substance type:Organic
- Physical state:Solid
- Storage : room temperature
- Expiry date : 2009-11-01
- Empirical formula : C27 H31 N3 O
- Water solubility : < 0.0007 mg/L
- Log KOW : 7.88 (moddeled data)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Sex: male and female
- Source: no data available
- Age at study initiation:
- Weight at study initiation: 2.5 to 3.4 kg
- Housing: The animals were conventionally kept in single cages under standardized conditions
- Diet (e.g. ad libitum): The diet consisted of a standard diet, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period:no data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-25 ° C
- Humidity (%): 40-60%
- Photoperiod (hrs dark / hrs light):dark-light rhythm of 12 hour
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 0.5g
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 0,24,48,72hours, 7 and 14 days
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: back of the ear
- % coverage: no data available
- Type of wrap if used: plaster bandages
REMOVAL OF TEST SUBSTANCE
- Washing (if done):
- Time after start of exposure:test sample was washed off with soap and water
OBSERVATION TIME POINTS
(indicate if minutes, hours or days) : 0, 24,48, 72 hours and 7, 14 days
SCORING SYSTEM:
- Method of calculation: The numerical recording of the effects was made by DRAIZE.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 14 d
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 14 d
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- no erythema or edema observed
Any other information on results incl. tables
Table 1: The animal-specific skin reactions and the skin irritation values are as follows:
Rabbit number |
Draize-grade after approximately |
stimulus value |
||||||||||||
0 |
24 |
48 |
72 |
7 |
14 |
E |
(ed) |
|||||||
E |
(ed) |
E |
(ed) |
E |
(ed) |
E |
(ed) |
E |
(ed) |
E |
(ed) |
|||
53 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
N |
N |
0 |
0 |
47 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
N |
N |
0 |
0 |
E = erythema / scab; (ED) = edema; N = no assessment
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- The primary skin irritant / Corrosion effects was on rabbits (Inner surface of the ears) tested. The overall score for erythema and edema formation after 7 days was 0.0 Following the EC Guideline for the Classification and Labeling of Hazardous Substances and Preparations (July 1983), the test chemical can to be considered as non-irritating to the skin.
- Executive summary:
The dermal irritation potential of the test chemical was assessed in New Zealand White rabbits.2 Albino rabbits (white New Zealand) of both sexes were used with a body weight of about 2.5 to 3.4 kg. The animals were conventionally kept in single cages under standardized conditions.
For the treatment of each animal, 0.5 g of the test sample was applied to a pulp pad and fixed to the hairless inside of a rabbit of 2 rabbits by means of plaster bandages. To better support the patch, a Stilck pulp was formed into a roll and tied into the ear. The exposure duration was 24 hours. Then the test sample was washed off with soap and water. Erythema and edema were observed and scored at 0, 24,48, 72 hours and 7, 14 days. The numerical recording of the effects was made according to DRAIZE.
The primary skin irritant / Corrosion effects was on rabbits (Inner surface of the ears) tested. The overall score for erythema and edema formation after 7 days was 0.0 Following the EC Guideline for the Classification and Labeling of Hazardous Substances and Preparations (July 1983), the test chemical can to be considered as non-irritating to the skin.
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