Registration Dossier
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EC number: 943-030-8 | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
LC50, 96h, Oncorhynchus mykiss = 509 mg/l (nominal)
Key value for chemical safety assessment
Additional information
Two studies were conducted on short-term toxicity to rainbow trout (Oncorhynchus mykiss) on the analogue substance. The first study (according to EU Method C.1) exposed groups of 10 animals to test item concentrations of 300, 350, 450, 500, 600 and 800 mg/l in reconstituted water for 96 hours, plus a control group of 10 animals were exposed to reconstituted water alone. Measured concentrations fell within 97.7 % to 108.3 % of nominal test item concentrations. A dose-response relationship with mortality was evident. The 96-hour LC50 of the test item was calculated to be 509.1 mg/l (nominal concentrations) using the LOGIT Model at 95 % confidence limits based on mortality.
The second study (according to the OECD Guideline 203, 1981) was a limit test according to the OECD Guideline 203 (1981) whereby 10 rainbow trout were exposed to 100 mg/l test item for 96 hours in a limit test, and a negative control group of 10 rainbow trout were exposed to test medium alone. Measured test item concentrations fell between 101.0 and 103.5 % of nominal concentrations. As no mortality was observed, the 96-hour LC50is therefore higher than 100 mg/l (nominal concentration).
Based on the read across considerations same results apply to the target substance and the LD50, 96h for fish is considered to be 509 mg/l.
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