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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 930-776-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to high standard, however, typical parameters not reported; no clinical observations, no blood biochemistry
Data source
Reference
- Reference Type:
- publication
- Title:
- Influence of particle solubility on the delivery of inhaled manganese to the rat brain: manganese sulfate and manganese tetroxide pharmokinetics following repeated (14-day) exposure
- Author:
- Dorman DC, Struve Mf, James RA, Marshall MW, Parkinson CU and Wong BA
- Year:
- 2 001
- Bibliographic source:
- Toxicology and Applied Pharmacology 170, 79-87
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Silicomanganese manufacturing fumes dedusting solid residues
- EC Number:
- 930-776-4
- IUPAC Name:
- Silicomanganese manufacturing fumes dedusting solid residues
- Details on test material:
- - Name of test material (as cited in study report): Manganese (II, III) tetraoxide
- Physical state: solid, crystalline powder
- Composition of test material, percentage of components: 72% Mn
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD (SD)BR
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Inc
- Age at study initiation: 8 week
- Housing: Rats were individually housed in suspended stainless steel cages with an automatic watering system.
- Diet (e.g. ad libitum): NIH-07 rodent chow available ad libitum except during exposure periods
- Water (e.g. ad libitum): Reverse osmosis purified water was available ad libitum
- Acclimation period: 2 weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18.5 - 21.5 °C
- Humidity (%): 40-50%
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Remarks on MMAD:
- MMAD / GSD: 1.5 - 2 µm with a geometric standard deviation <2
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus:1-m3 chamber
- Method of holding animals in test chamber:
- Source and rate of air:
- Method of conditioning air:
- System of generating particulates/aerosols: Atmospheres were generated as dry powder using a Wright Dust Feeder with a delivery pressure of 25 psi.
- Temperature, humidity, pressure in air chamber: measured every 30 mins, temperature maintained at 22.2°C. Relative humidity was maintained at 30-70% with a target of 50%.
- Air flow rate: 200-250 L/min
- Air change rate: 12-15 /hour
- Method of particle size determination:
- Treatment of exhaust air:
TEST ATMOSPHERE
- Brief description of analytical method used: Optical particle sensor
- Samples taken from breathing zone: yes - Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 14 days
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.042, 0.42 and 4.2 mg / Mn3O4/m3
Basis:
nominal conc.
- No. of animals per sex per dose:
- 12 males per dose
- Control animals:
- yes
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Tissue manganese concentrations: Increased lung Mn concentrations were observed following exposure to ≥0.3mg Mn/m3. Increased olfactory bulb concentrations were observed following exposure to 3 mg Mn/m3. Increased femur and bile concentrations were observed following exposure to 3 mg Mn/m3.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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