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EC number: 419-370-3 | CAS number: 84632-66-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Absorption, distribution, metabolism and excretion of the test item were not examined. Reliable data on a structural analogue are available. For this purpose, 14C-labelled substance was administered orally at two target dose levels of 100 mg/kg (low dose) and 1000 mg/kg (high dose) to male rats and radioactivity appearing in urine, feces, blood/plasma and organs/ tissues was followed for 168 hours. At both dose levels, the very low radioactivity levels found in blood and plasma as well as the minimal amounts excreted via the urine indicated 1 that 14C-material was absorbed to a negligible extent and therefore not bioavailable after single oral administration to rats within the used dose range.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Absorption, distribution, metabolism and excretion of the test item were not examined. Reliable data on a structural analogue are available. Both substances are pigments and share high similarity in structure and are of low solubilitx in water (< 0.1 mg/l). The analogue has a slightly higher molecular weight which gives an additional safety margin.
To evaluate a possible toxicological hazard and the bioavailability of the test material (analogue) in man, the objectives of the present toxicokinetic study were to follow the absorption, distribution and excretion in rats. For this purpose, 14C-labelled substance was administered orally at two target dose levels of 100 mg/kg (low dose) and 1000 mg/kg (high dose) to male rats and radioactivity appearing in urine, feces, blood/plasma and organs/ tissues was followed for 168 hours. Due to lack of solubility of the test article, actual amounts of 14C-material present in the various stock suspertsions and suspensions for application were only indirectly determined by means of weighing.At 168 hours after the administration, only very low amounts (0.3 % and 0.6 %) of radioactivity were found in the urine at the low and high dose level, respectively. Already after 24 hours, radioactivity in the urine amounted to 0.3 % and 0.4 %, respectively, and may for the most part originate from a contamination via the feces. Accordingly, excretion of the compound proceeded almost exclusively via the feces and amounted after 168 hours, on average, to 119.7 % and 96.0 % at the low and high dose level, respectively. Already after 24 hours, fecal excretion accounted for 101.4 % (low dose level) and 79.7 % (high dose level) of the radioactivity administered. Together with the cage wash (1.8 % and 7.7 %), total excreted radioactivity amounted to 121.5 % and 104.3 % at the low and high dose level, respectively. Taking into account the very low radioactivity levels found in blood and plasma, no elimination kinetics and no area under the curves could be calculated. Except for intestinal tract with contents, residual radioactivity levels found at 168 hours after low and high dose level administration in all organs/tissues, blood/plasma and residual carcass were negligible.
In conclusion, at both dose levels, the very low radioactivity levels found in blood and plasma as well as the minimal amounts excreted via the urine indicated 1 that 14C-material was absorbed to a negligible extent and therefore not bioavailable after single oral administration to rats within the used dose range.
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