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EC number: 700-421-6 | CAS number: 1215122-81-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral:
-rat, LD50 (C12DMA): 1220 mg/kg (male)
-rat, LD50 (C12DMA): 1890 mg/kg (male); 1450 mg/kg (female)
-rat, LD50 (C14DMA): >1600 mg/kg (male); 1320 mg/kg (female)
-rat, LD50 (C14DMA): 2166 mg/kg (male/female)
-rat, LD50 (C16DMA): 1015 mg/kg (male/female)
-rat, LD50 (C16DMA): 2000 mg/kg (male); >2000 mg/kg (female)
-rat, LD50 (C12-14DMA): >2000 mg/kg (male); 1015 mg/kg (female)
-rat, LD50 (C12-18DMA): 1500 mg/kg (male); 1300 mg/kg (female)
-rat, LD50 (C12-18DMA): >2000 mg/kg (male/female)
-rat, LD50 (C12-18DMA): 1000-1250 mg/kg (male/female)
-rat, LD50 (C18DMA): 2116 mg/kg (male/female)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
There is no experimental data on acute toxicity for the registration substance N,N-dimethyl-C12-16-(even numbered)-alkyl-1-amines, lactates. The acute toxicity of the registration substance is derived from the available data of dimethyl alkylamines (DMAs) with comparable length of alkyl chain (source substances).
No acute toxicity potential was derived some aucte oral studies in rats with C14DMA, C16DMA, C18DMA, C12-18DMA and C12 -14 DMA (LD50 > 2000 mg/kg). However, in other studies of C12DMA, C14DMA, C16DMA and C12 -18DMA there is data indicating the LD50 is in the range of 1000 -1890 mg/kg.
Considering all the information available, the LD50 of the registration substance is considered to be greater than 1000 mg/kg. Therefore, the registration substance is classified as Cat.4 for acute oral toxicity,according to the criteria laid down in the EU Dangerous Substances Directive (67/548/EEC) and in the EU Classification Labelling and Packaging Regulation (1272/2008/EC).
Justification for classification or non-classification
Based on the available data, the substance is classified as Cat.4 for acute oral toxicity,according to the criteria laid down in the EU Dangerous Substances Directive (67/548/EEC) and in the EU Classification Labelling and Packaging Regulation (1272/2008/EC).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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