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EC number: 219-607-9 | CAS number: 2478-20-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 November 2016 to 15 January 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2014
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- 1998
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- column elution method
- Specific details on test material used for the study:
- - Purity/composition correction factor: Yes, correction factor is 1.031 according to active ingredient
- Key result
- Water solubility:
- 4.06 mg/L
- Conc. based on:
- act. ingr.
- Temp.:
- 20 °C
- pH:
- 7.6
- Details on results:
- The coefficient of variation (CV) (n = 10) was ≤ 30 % at both flow rates (24 and 12 mL/h). It demonstrated that the system was equilibrated at all flow rates.
The maximum difference (MD) on the mean values of the samples at both flow rates was also ≤ 30 %. Based on this, the water solubility of the test material is given as the mean value of these measurements.
The mean value for the 24 and 12 mL/h hour flow rates were 4.13 and 3.99 mg a.i./L, respectively, with coefficients of variation of 0.63 and 0.40, respectively.
The turbidity of the eluates at a flow rate of 12 and 24 mL/h was 0.647 and 0.355 NTU, respectively. However, the results were accepted since this had no effect on the study results.
No test material was detected in the samples from the blank column. - Conclusions:
- The water solubility of the test material at 20 °C was 4.06 mg a.i./L (pH 7.6).
- Executive summary:
The water solubility of the test material was determined in accordance with the standardised guidelines OECD 105, EU Method A.6 and US EPA OPPTS 830.7840 under GLP conditions.
Following a preliminary study, the column elution method was considered to be the most appropriate.
A test material solution was prepared in acetone and mixed with column material. Acetone was completely evaporated and a suitable column was filled with the carrier material. Double distilled water was pumped through the column until it was completely filled. The system was allowed to equilibrate for two hours.
After the stabilisation period, the column was eluted with double distilled water at a flow rate of 24 mL/hour. Ten consecutive samples of 2 mL were taken. The flow was halved to 12 mL/hour and ten consecutive samples of 2 mL were taken. Analysis was performed on subsamples of 0.6 mL. The samples were diluted in a 3:2 (v:v) ratio with acetonitrile and analysed. The column elution method was performed at 19.9 ± 0.2 °C.
The water solubility of the test material at 20 °C was 4.06 mg a.i./L (pH 7.6).
Reference
Description of key information
The water solubility of the test material at 20 °C was 4.06 mg a.i./L (pH 7.6).
Key value for chemical safety assessment
- Water solubility:
- 4.06 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test material was determined in accordance with the standardised guidelines OECD 105, EU Method A.6 and US EPA OPPTS 830.7840 under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
Following a preliminary study, the column elution method was considered to be the most appropriate.
A test material solution was prepared in acetone and mixed with column material. Acetone was completely evaporated and a suitable column was filled with the carrier material. Double distilled water was pumped through the column until it was completely filled. The system was allowed to equilibrate for two hours.
After the stabilisation period, the column was eluted with double distilled water at a flow rate of 24 mL/hour. Ten consecutive samples of 2 mL were taken. The flow was halved to 12 mL/hour and ten consecutive samples of 2 mL were taken. Analysis was performed on subsamples of 0.6 mL. The samples were diluted in a 3:2 (v:v) ratio with acetonitrile and analysed. The column elution method was performed at 19.9 ± 0.2 °C.
The water solubility of the test material at 20 °C was 4.06 mg a.i./L (pH 7.6).
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