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Diss Factsheets
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EC number: 255-272-5 | CAS number: 41233-93-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No studies for acute toxicity with potassium 2-methylbutan-2-olate are available. According to the REACh Regulation (EC) No 1907/2006, Article 18.2 no further studies need to be conducted. The available dataregarding skin irritation demonstrate that potassium 2-methylbutan-2-olate has a corrosive potential to skin. According to the REACh Regulation (EC) No 1907/2006, Annex VII and Annex VIII, column 2 point 8.5 a study of acute toxicity does not need to be performed if the substance is classified as corrosive to skin. The test substance is classified as skin corrosive, category 1A according to CLP Regulation (EC) No. 1272/2008.
The test substance hydrolyses rapidly in contact with water into 2-methylbutan-2-ol and potassium hydroxide. Therefore, the hydrolysis products are considered to be relevant for acute toxicity.
Justification for classification or non-classification
The test substance hydrolyses rapidly in contact with water. Therefore, the hydrolysis products are considered to be relevant for classification according to CLP Regulation (EC) No 1272/2008. For both hydrolysis products, potassium hydroxide (CAS No. 1310-58-3) and 2-methylbutan-2-ol (CAS No. 75-85-4), disseminated dossiers are available on the homepage of ECHA. Potassium hydroxide is classified for acute oral toxicity, category 4, according to Annex VI of the CLP regulation. The second product 2-methylbutan-2-ol (CAS No. 75-85-4) is not classified as orally toxic. However, it is classified as acute toxic category 4 by inhalation route according to Annex VI of the CLP Regulation (EC) No 1272/2008 and is classified as acute toxic by the dermal exposure route according to the disseminated dossier. Based on this data, the test substance should also be classified as acute toxic, category 4 by oral, dermal and inhalative route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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