Registration Dossier
Registration Dossier
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EC number: 810-151-1 | CAS number: 1050477-44-5
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Type of method:
- flask method
- Water solubility:
- 0.29 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- 3 d
- Temp.:
- 20 °C
- pH:
- 5
- Details on results:
- The relative standard deviation between the single determinations is < 15 %. The validity criteria have therefore been met.
- Conclusions:
- The water solubility of CN-ethyl-TH-naphthyridin in demineralized water at 20 °C is determined to be: 0.29 mg/L.
- Executive summary:
The water solubility of CN-ethyl-TH-naphthyridin in demineralized water was determined with the shake flask method at 20 °C according to OECD 105 and showed a value of 0.29 mg/L (mean value) at 20 °C (no pH-value was reported). The mean pH-value of the three measurements was approx. 5.
Reference
In a preliminary test, the water solubility of the test item was found to be 0.4 mg/L. The shake flask method is, according to the guideline, applicable to a water solubility above 10-2 g/L only. In a pretest the water solubility was determined to be approx. 0.4 mg/L. A test with the column method showed that coating of the test item on the loading material didn´t work. Therefore the water solubility was determined by flask method.
Description of key information
The water solubility of CN-ethyl-TH-naphthyridin in demineralized water was determined with the shake flask method at 20 °C according to OECD 105 and showed a value of 0.29 mg/L (mean value) at 20 °C.
Key value for chemical safety assessment
- Water solubility:
- 0.29 mg/L
- at the temperature of:
- 20 °C
Additional information
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