Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-619-1 | CAS number: 144-19-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24-hour application followed by 14-day observation period
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted prior to introduction of Good Laboratory Practices; data from a summary report; limited number of animals. Study was conducted by an internal Eastman Kodak Company method, developed prior to established guidelines. The results of this study are valid for classification insofar as the conditions of exposure are at least as stringent as modern guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Deviations:
- not specified
- Principles of method if other than guideline:
- Method is an in vivo study using three guinea pigs. Following depilation of the abdomen of each animal, a single dose of the test substance was applied under an occlusive wrap for 24 hours. Animals were observed periodically for mortality, and on Days 7 and 14 for dermal reactions. In addition, 14-day weight changes were recorded.
- GLP compliance:
- no
- Remarks:
- Study conducted prior to GLPs
- Test type:
- other: internal Eastman Kodak method
- Limit test:
- no
Test material
- Reference substance name:
- 2,2,4-trimethylpentane-1,3-diol
- EC Number:
- 205-619-1
- EC Name:
- 2,2,4-trimethylpentane-1,3-diol
- Cas Number:
- 144-19-4
- Molecular formula:
- C8H18O2
- IUPAC Name:
- 2,2,4-trimethylpentane-1,3-diol
- Details on test material:
- -Identity (according to study report): 2,2,4-trimethyl-1,3-pentanediol (TMPD)
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Following depilation of each animal's abdomen, a single dose of 0.25, 0.5, or 1.0 g/kg bw of the test substance (dose preparation: neat) was applied under an occlusive cuff and wrap. The test substance was moistened with water before administration. After a 24 hour exposure period, the cuffs and wrappings were removed.
- Duration of exposure:
- 24 hours
- Doses:
- 0.25, 0.50 or 1.0 g/kg bw
- No. of animals per sex per dose:
- 1 animal/dose (sex not specified)
- Control animals:
- no
- Details on study design:
- Three guinea pigs (sex, age, and initial weights not provided) were used. Following depilation of the guinea pig abdomens, a single dose of 0.25, 0.50, or 1.0 g/kg bw of the test substance (dose preparation: neat) was applied under an occlusive wrap prepared from a pad of gauze held in place with an impervious cuff made of rubber dental dam material. The test substance was moistened with water prior to administration. The cuff was wrapped securely around the torso of the guinea pig and held in place with non-irritating tape. Animals were exposed for 24 hours; then the cuffs were removed. Animals were observed for mortality, and on Days 7 and 14 for dermal reactions. Guinea pigs were weighed prior to administration of the test substance and at termination of the 14-day observation period to measure weight changes during the study.
- Statistics:
- not performed
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 1 other: g/kg bw
- Mortality:
- None
- Clinical signs:
- other: Signs of irritation at the application site included slight to moderate edema, erythema (grade 2), and scattered necrosis after removal of the bandage and cuff. Gross edema, eschars and little hair were noted 1 week after dose administration. Slight eryt
- Gross pathology:
- Not performed
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified (NC) for any endpoint in Directive 67/548/EEC; insufficient data for UN GHS or EU CLP Regulation (EC) No. 1272/2008 acute dermal toxicity classification. NC for STOT-SE per UN GHS or EU CLP; Cat 2 for skin irritation per UN GHS and EU CLP.
- Remarks:
- Criteria used for interpretation of results: OECD GHS
- Conclusions:
- In an acute dermal toxicity test, no deaths were reported when up to 1 g/kg bw of neat 2,2,4-trimethyl-1,3-pentanediol was applied to the clipped skin of guinea pigs for twenty-four hours under occlusive wrap. No clinical signs were reported during the study. Two of three animals gained weight normally while the third lost weight. Insufficient data were provided to determine if the weight loss was dose related. Slight erythema and scarring was still evident along the top of the patch at the conclusion of the observation period. The dermal LD50 in guinea pigs was > 1.0 g/kg bw, the highest dose tested in this study.
2,2,4-Trimethyl-1,3-pentanediol was not acutely toxic by the dermal route in rats at a dose of 1000 mg/kg bw and is not classified for acute lethality by the dermal route according to Directive 67/548/EEC. There were insufficient data to determine if the test material was classifiable according to the UN Globally Harmonized System of Classification and Labelling of Chemicals (GHS) or EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) 1272/2008 since Category 4 in those two classification schemes covers the dose range 1000-2000 mg/kg bw. Based on an absence of signs of systemic toxicity and/or skin absorption, 2,2,4-trimethyl-1,3-pentanediol is not classified according to the UN Globally Harmonized System of Classification and Labelling of Chemicals (GHS) or EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) 1272/2008 for Specific Target Organ Toxicity – Single Exposure. Based on signs of dermal irritation still present at the conclusion of the two week observation period, 2,2,4-trimethyl-1,3-pentanediol may be classifiable for Skin Irritation/Corrosion according to the UN Globally Harmonized System of Classification and Labelling of Chemicals (GHS) and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) 1272/2008. The conditions of exposure in this study were much more stringent, both in dose used and exposure period, than what is currently used in guideline skin irritation studies. - Executive summary:
In an acute dermal toxicity study, 3 guinea pigs were exposed to 0.25, 0.5, or 1.0 g/kg bw 2,2,4-trimethyl-1,3-pentanediol under occlusive contact for 24 hours. Under the conditions of this study, no deaths occurred and the dermal LD50 was considered to be > 1 g/kg bw of the neat material. No signs of skin absorption or systemic toxicity were evident during the study. Signs of irritation at the application site included slight to moderate edema, erythema (grade 2), and scattered necrosis after removal of the bandage and cuff. Gross edema, eschars and little hair were noted at week 1 post-dose and slight erythema, scarring along the edge of the patched area, sparse hair, and desquamation was noted 2 weeks post-dose. A body weight gain was noted in two of three animals while the remaining animal lost weight over the 2-week observation period. Based on the results of this study, 2,2,4-trimethyl-1,3-pentanediol presents a low acute toxicity hazard upon skin contact under conditions of normal use.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.