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EC number: 290-058-5 | CAS number: 90063-97-1 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Mentha arvensis, Labiatae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- other: Known constituent approach
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Cornmint oil is a Natural Complex Substance (NCS). With 98.8% of the constituents of Cornmint Oil known, this NCS can be considered as a well defined NCS. The constituents of Cornmint oil are predominantly cyclic monoterpene alcohols (menthol) and ketones (menthone). In the typical Cornmint oil, these constituents form 87% of total. If the constituents of the NCS are readily biodegradable, the NCS itself is considered to be readily biodegradable as well.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 310 (Ready Biodegradability - CO2 in Sealed Vessels (Headspace Test)
- Principles of method if other than guideline:
- Assessment of the Ready biodegradability of the known constituents; addition of the percentage of readily biodegrabable constituents in the mixture gives the fraction of ready biodegradable substances. If this fraction exceeds 75%, the NCS is classified as 'readily biodegradable'.
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- mixture of sewage, soil and natural water
- Remarks:
- several guideline tests with different inocula were used
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Parameter followed for biodegradation estimation:
- O2 consumption
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- > 60
- Remarks on result:
- other: L-menthol, iso- Menthone, 1,8-cineole, Sabinene, beta-carophyllene, L-limonene
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- > 60
- Remarks on result:
- other: Menthone, alpha-Pinene, beta-Myrcene
- Key result
- Parameter:
- not specified
- Value:
- > 60
- Remarks on result:
- other: Based on read across from structural analogy and BIOWWIN prediction
- Remarks:
- Neo- Menthol, Menthyl Acetate, Pulegone, Iso-pulegol, beta-pinene, Piperitone, Octan-3-ol, Neo-iso Menthol, Neo-iso pulego
- Parameter:
- % degradation (O2 consumption)
- Value:
- < 60
- Remarks on result:
- other: Germacrene D
- Details on results:
- Details for all constituents are summarised in window "Any other information on results" and in attached document
- Validity criteria fulfilled:
- not applicable
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Cornmint oil is considered to be readily biodegradable.
- Executive summary:
Cornmint oil is a Natural Complex Substance (NCS) for which > 90% of the constituents is identified. The main constituents in Cornmint oil are predominantly cyclic monoterpene alcohols (like menthol) and ketones (like menthone). As no valid empirical results from a test for the ready biodegradation of Cornmint oil are available, the assessment is based on its constituents. The assumption is that if the constituents of the NCS are readily biodegradable, the NCS itself is readily biodegradable as well.
83 % of the volume of constituents are shown to be readily biodegradable based in experimental results of the constituents. For 6 constituents (15 %) the ready biodegradability is based on structurally related substances.
Thus 98% of the composition of this NCS is in the category of ready biodegradable substances. Therefore, Cornmint oil is considered as readily biodegradable.
Reference
Assessment of the biodegradability of Cornmint oil:
Each of the identified constituents, totalling 95 -98% of the composition, is readily biodegradable, see underlying data in table below.
Constituent |
Results of biodegradation assessment |
L-menthol C10 H20 O |
READILY BIODEGRADABLE: - OECD 301D (Closed Bottle test): 79 – 92 % (TNO 2003 /Haarmann & Reimer) |
Menthone C10H18O |
READILY BIODEGRADABLE: - OECD 301B: 99.5% under CAS 89-80-5 (Quest 1996) |
Iso-Menthone C10H18O |
READILY BIODEGRADABLE: - OECD 301D (Closed bottle test): 63% (Symerise 1999) |
L-Limonene C10H16 |
READILY BIODEGRADABLE: - Headspace CO2: 71.4% (Quest 1993). The biodegradability of perfume ingredients in the sealed vessel test. - MITI (I) / OECD 301C, improved for volatile substance: Limonene 14d - BOD: 41, 81, 98% Direct analysis: GC: 100%; TOC 50, 73, 81% (MITI 1980 http://www.safe.nite.go.jp/sitemap/db_map_e.html) - Readily biodegradable (Misra, G.; Pavlostathis, S. G.; Perdue, E. M.; Araujo, R. Applied Microbiology and Biotechnology, 1996, 45(6), 831-838.) |
Neo-Menthol C10 H20 O |
Expected to be READILY BIODEGRADABLE Isomer of l-menthol CAS 2216-51-1 (see row 1 in this table) |
Menthyl Acetate C12H22O2 |
Expected to be READILY BIODEGRADABLE Ester cleavage by hydrolysis to acetic acid and menthol Both transformation products are readily biodegradable
Supported by SRC-BIOWWIN prediction |
Pulegone C10H16O |
Expected to be READILY BIODEGRADABLE Structural analogy with isomenthone & menthone (row 3 and row 2 in this table) Both are readily biodegradable
Expected Pathway: Oxidation of cyclic keton to cyclic ester (mono-oxygenase), next ester cleavage and further degradation (UM-PPS) |
Iso-pulegol C10H18O |
Expected to be READILY BIODEGRADABLE Structural analogy with menthol (row 1 in this table, readily biodegradable)
Supported by SRC-BIOWWIN prediction |
Alpha-Pinene C10H16
|
READILY BIODEGRADABLE: - OECD301B, sealed vessels: 62% (28d), 70% (42d) (Astra Zeneca, 2001, ECB PBT#84 http://ecb.jrc.ec.europa.eu/documents/PBT_EVALUATION/PBT_sum084_CAS_91770-80-8.pdf). - MITI (I) / OECD 301C: 28d - BOD: 91, 90, 95% Direct analysis: GC: 100, 100, 100% (MITI 2007: http://www.safe.nite.go.jp/sitemap/db_map_e.html) |
beta-pinene C10H16 |
READILY BIODEGRADABLE: Read-across froma-Pinene, based on structural analogy Supporting evidence from: - OECD301B, sealed vessels Gum turpentine (50.9% alpha-pinene, 36.8% beta-pinene): 52% mineralisation in 28d (Astra Zeneca, 2001, ECB PBT#84). This high level of biodegradation cannot be caused by degradation only of a-pinene, so also b-pinene is degraded. |
Piperitone C10H16O |
Expected to be READILY BIODEGRADABLE Structural analogy with isomenthone & menthone (row 3 and row 2 in this table) Both are readily biodegradable
Expected Pathway: Oxidation of cyclic keton to cyclic ester (mono-oxygenase), next ester cleavage and further degradation (UM-PPS) |
Octan-3-ol C8H18O |
READILY BIODEGRADABLE structural analogues: 1-octanol: MITI-I (OECD 301C), 28d 89% BOD, DIrect analysis TOC 99%, GC 100% (2002) octan-2-ol: MITI-I (OECD 301C), 14d 76% BOD, DIrect analysis TOC 96%, GC 100% (2000) 2-ethylhexanol: MITI-I (OECD 301C), 14d 99.9 & 79 % BOD, DIrect analysis TOC 100%, GC 100% (1977) http://www.safe.nite.go.jp/sitemap/db_map_e.html |
Neo-iso menthol C10 H20 O |
Expected to be READILY BIODEGRADABLE Isomer of l-menthol CAS 2216-51-1 (see row 1 in this table) |
Neo-iso pulegol C10H18O |
Expected to be READILY BIODEGRADABLE Structural analogy with menthol (row 1 in this table, readily biodegradable)
Supported by SRC-BIOWWIN prediction |
Germacrene D C15H24 |
Not readily biodegradable - OECD301F - 19% 28d, 24% 63d, specific analysis at the end of the test provided evidence of complete primary degradation of Germancrene-D (Givaudan, 2008). |
1,8-cineole C10H18O |
READILY BIODEGRADABLE: - OECD 301B, sealed CO2: 91% (Quest 1995); - OECD 301F:82% (Givaudan 1997) |
beta-Myrcene C10H16O
|
READILY BIODEGRADABLE: - OECD 310 Carbon Dioxide Headspace test: CO2 production: 73% (Van Ginkel 2009) - MITI (I) / OECD 301C, improved for volatile substance: 14d - BOD: 86% Direct analysis: GC: 99%; TOC: 97% (MITI 1987: http://www.safe.nite.go.jp/sitemap/db_map_e.html)
|
Sabinene C10H16 |
READILY BIODEGRADABLE: - OECD 301F: 76% in 28d (Givaudan 2010) Sabinene (72% pure with 27% beta-pinene) |
beta-caryophyllene C15H24 |
READILY BIODEGRADABLE: - OECD301F - 75% (REF: Givaudan, 2007) |
Fraction of NCS readily biodegradable (tests) Including constituents expected to be readily biodegradable |
|
The complete asssessment is added attached to this study record. Studies mentioned by Company Name are included in the RIFM database.
Description of key information
Cornmint oil is a Natural Complex Substance (NCS) for which > 98% of the constituents is identified. The asssessment of the biodegradation of Cornmint oil is based on its constituents. 83 % and probably up to 98% of constituents forming this NCS are in the category of ready biodegradable substances. Therefore, Cornmint oil is considered as readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Cornmint oil is a Natural Complex Substance (NCS) for which > 98% of the constituents is identified. The main constituents in Cornmint oil are predominantly cyclic monoterpene alcohols (like menthol) and ketones (like menthone) comprising more then 85% of the composition. As no valid empirical results from a test for the ready biodegradation of Cornmint oil are available, the assessment is based on its constituents. The assumption is that if the constituents of the NCS are readily biodegradable, the NCS itself is readily biodegradable as well.
83 % of the volume of constituents are shown to be readily biodegradable based in experimental results of the constituents. For 6 constituents (15 %) the ready biodegradability is based on structurally related substances.
The constituents, comprising 83 % and probably up to 98% of the composition of this NCS, are in the category of ready biodegradable substances. Therefore, Cornmint oil is considered as readily biodegradable.
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