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EC number: 203-294-0 | CAS number: 105-39-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Publication not peer reviewed
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 946
Materials and methods
- Principles of method if other than guideline:
- No data provided on the method.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ethyl chloroacetate
- EC Number:
- 203-294-0
- EC Name:
- Ethyl chloroacetate
- Cas Number:
- 105-39-5
- Molecular formula:
- C4H7ClO2
- IUPAC Name:
- ethyl 2-chloroacetate
- Details on test material:
- - Name of test material (as cited in study report): Ethyl chloroacetate
- Physical state: liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: only data: albino
Test system
- Vehicle:
- other: propylene glycol or water
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit):0.005 mL undiluted substance, 1% solution and 5 % solution.
Guided by the result and the table of injury grades below, additional applications are made until the chemical can be assigned to one of the grades we recognize. - Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 24 h
- Number of animals or in vitro replicates:
- 5 animals per dose
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): No
SCORING SYSTEM:
System for numerical scoring of injury to the rabbit eye:
Symptom Visible Before Fluorescein Staining Max
Cornea dull 2
Cornea opaque, less than half of area 4
Cornea opaque, more than half of area 6 6
Keratoconus 6
Iritis, slight internal congestion 1
Iritis, marked internal congestion 2 2
Symptom Visible After Fluorescein Staining
(if necrosis is diffuse assign points corresponding to half observed area)
Necrosis on less tban 5 % of cornea 1
Necrosis on 5 to 12% 2
Necrosis On 13 to 37% 3
Necrosis on 38 to 62 % 4
Necrosis on 63 to 87% 5
Necrosis on SS to 100% 6 6
Total 20
Grades of injury employed for rating the relative damage produced by chemicals in the eye:
Grade 1. 0.5 mL undiluted gives injury of 0 to 1.0 points
Grade 2. 0.5 mL undiluted gives injury of over 1.0 up to 5.0 points.
Grade 3. 0.1 mL undiluted glves lnJury of up to 5.0 points (0.5 mL gives over 5.0).
Grade 4. 0.02 mL undiluted gives injury of up to 5.0 points (0.1 mL gives over 5.0).
Grade 5. 0.005 mL undiluted gives injury of up to 5.0 points (0.02 mL gives over 5.0).
Grade 6. Excess of 40% solution gives injury of up to 5.0 points (0.005 mL gives over 5.0).
Grade 7. Excess of 15% solution gives injury of up to 5.0 points (40 % gives over 5.0).
Grade 8. Excess of 5% solution gives injury of up to 5.0 points (15 % gives over 5.0).
Grade 9. Excess of 1% solution gives injury of up to 5.0 points (5 % gives over 5.0).
Grade 10. Excess of 1% solution gives injury of over 5.0 points.
TOOL USED TO ASSESS SCORE:
Eighteen to 24 hours after the application, the eye is examined in strong diffuse daylight, then stained with a 5-percent aqueous solution of fluorescein, and the injury scored.
Results and discussion
Any other information on results incl. tables
Ethyl chloroacetate is arranged as Grade 9 (0.005 mL undiluted substance and a 5% solution yield scores of over 5.0, a 1% solution not over 5.0) according to the injury grade.
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Described in Details on study design
- Conclusions:
- Ethyl chloroacetate is arranged as Grade 9 (0.005 mL undiluted substance and a 5% solution yield scores of over 5.0, a 1% solution not over 5.0) according to the injury grade observed. So it is considered as highly irritant.
- Executive summary:
The irritant effect of ethyl chloroacetate on the eyes was examined in a tests on albino rabbits. The test substance showed a strong irritant effect (step 9 on a scale of 10 indicating increasing irritant effect). The authors pointed out that ethyl chloroacetate is also known for its strong irritant effect on the human eye.
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