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Diss Factsheets
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EC number: 208-060-1 | CAS number: 506-93-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Hydrolysis:
Based on hydrolysis of a structural analog substance a hydrolysis half live of > 1 year was deducted
Photodegradation
Due to the low vapour pressure the substance under investigation will not be present in the gas phase in the atmosphere in appreciable amounts and therefore the elimination path photodegradation in air will be only of minor importance.
Biodegradation:
Guanidine nitrate is inherently biodegradable. This was proved in a non guideline study (Mitchell 1987). Test conditions especially test substance concentration and bacteria concentration are comparable to a OECD301 guideline study, inoculum is expected to be adapted. Guanidinenitrat is also biodegradable under less favourable conditions as was demonstrated in degradation tests with 14-C Guanidine in river water and aerated soil.
Degradation tests with 8 river water samples from different locations showed a mean degradation half life for guanidine of 5.25 d at 25°C after a mean lag phase of 30 d.
The salt Guanidine nitrate consists of the Guanidinium-Cation and Nitrate-Anion. Nitrate-salts are widely used as Nitrogen plant fertilizers. Plants metabolize the Nitrate-anioin for their nitrogen nutrition and thus quickly reduze it's concentration in soils and water as long as the Nitrate concentration doesn't reach toxic levels.
The river water die away test showed that the development of the microbial populations capable of enhanced guanidinium mineralization is related to the concentration of the cation. At the three highest concentrations (0.1 - 10 mg/l), a biodegrading population developed that ultimately effected the persistence of the 14-C guanidinium cation. Mineralization occurred also at 3 guanidinium concentrations tested from 0.0005 - 0.01 mg/l but not with a similar extensive mineralization rate as at 0.1 - 10 mg/ Guanidinium /L and mineralization rate developed more slowly as at 0.1 mg/L.
Both from direct observations in surface water samples (other experiments in the publication) and from the evaluation of an enriched laboratory population, the development of such a population as well as its degradation of guanidinium would likely be slow.
14-C Guanidinium in aerated soil is biodegraded with a half live of 2.5 - 8 days for guanidine concentrations of 2.5 – 100 mg/kg dw. The degradation rate is dependent on the concentration of guanidinium with a lower degradation rate at high concentrations, on the type of soil used and on the availability of carbon sources (Glucose or Cellulose) which enhance mineralization rate. Nitrogen in form of Ammonium, Nitrate, Nitroguanidine only slightly inhibit guanidinium mineralization.
Bioaccumulation:
In accordance with column 2 of REACH Annex IX, the study on bioaccumulation (required in section 9.3.2) does not need to be conducted as the substance has a low potential for bioaccumulation (measured log Kow < -1.7).
Transport and distribution:
In accordance with REACH Annex IX, the study on "Further information on adsorption/desorption" (required in section 9.3.3) does not need to be conducted as the substance has a low potential for bioaccumulation (measured log Kow < -1.7).
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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