Registration Dossier
Registration Dossier
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EC number: 282-758-4 | CAS number: 84402-58-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2003-10-22 till 2004-03-27
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with GLP without deviations.
- Justification for type of information:
- QSAR not applicable for organic salt compound MPAAU.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Methylphosphonic acid, compound with amidinourea (1:1)
- EC Number:
- 282-758-4
- EC Name:
- Methylphosphonic acid, compound with amidinourea (1:1)
- Cas Number:
- 84402-58-4
- Molecular formula:
- C2H6N4O.CH5O3P
- IUPAC Name:
- Phosphonic acid, P-methyl-, compd. with N-(aminoiminomethyl)urea (1:1)
- Details on test material:
- technical product
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipping
- Vehicle:
- water
- Controls:
- other: The untreated other side served as control.
- Amount / concentration applied:
- 0.5 ml technical product
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- Animals were examined for signs of erythema and oedema at 1, 24, 48 and 72 hours after patch removal.
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no effect
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no effect
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no effect
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no effect
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no effect
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no effect
- Irritant / corrosive response data:
- none
- Other effects:
- no effect observed.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- As the mean value for erythema or oedema were "0" for all 3 animals after a test period of 4h and a observation period of 24,48 and 72 h, the test material is be considered as a "non irritant".
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