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EC number: 203-919-7 | CAS number: 111-90-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A published study containing sufficient details to regard it as reliable for use in hazard assessment. Limited experimental detail provided.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- In vivo and in vitro toxicity of Carbitol
- Author:
- Berte F
- Year:
- 1 986
- Bibliographic source:
- Boll Chim Farm 125, 401-403
- Reference Type:
- publication
- Title:
- In vivo and in vitro toxicity of Carbitol
- Author:
- Berte F
- Year:
- 1 987
- Bibliographic source:
- Chem Abst 107 (3) 19235
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- Deviations:
- yes
- Remarks:
- one sex only; only 4 animals in control group; only 1000 PCE for each animal were scored.
- GLP compliance:
- not specified
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- 2-(2-ethoxyethoxy)ethanol
- EC Number:
- 203-919-7
- EC Name:
- 2-(2-ethoxyethoxy)ethanol
- Cas Number:
- 111-90-0
- Molecular formula:
- C6H14O3
- IUPAC Name:
- 2-(2-ethoxyethoxy)ethan-1-ol
- Details on test material:
- Test material was CARBITOL. Purity was not listed.
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- 20-30g
Sourced from Charles River
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- no data
- Details on exposure:
- i.p.
- Duration of treatment / exposure:
- 2 days
- Frequency of treatment:
- daily
- Post exposure period:
- One group of animals treated with test material and BP was killed at 48 hours, and the other was killed at 72 hours. Negative controls were killed at 72 hours.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2ml/kg/day
Basis:
nominal conc.
- No. of animals per sex per dose:
- 2 groups of 4 animals for test material and positive control
1 group of 4 animals for controls. - Control animals:
- yes, concurrent no treatment
- Positive control(s):
- 100 mg/kg benzoapyrene (BP) dissolved in DMSO
Examinations
- Tissues and cell types examined:
- Bone marrow .
- Details of tissue and slide preparation:
- Bone marrow smears were made according to the method of Schmitd et al (in 'Chemical Mutagens: Principles and methods for their detection', A. Hollaender and FJ Serres (eds) vol.4, 31-53, Plenum Press, New York, 1976), and stained with Giemsa.
- Evaluation criteria:
- One thousand polychromatic erythrocytes (PCE) from each animal were scored for micronuclei. The PCE/normochromatic erythrocyte ratio (NCE) was also scored to evaluate any toxic effect.
- Statistics:
- Not statistically analysed
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- not specified
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Any other information on results incl. tables
Test material had no effect on the number of NCE (1738 and 2010 in carbitol treated at 48 and 72 hrs, respectively vs. 1516 in control), ratio of PCE/NCE (2.30 and 1.99 in treated at 48 and 72 hrs, respectively vs. 2.64 in control), or on the number of micronuclei in PCE (1 at both time points, vs. 2 in negative control). The number of NCE was increased by treatment with BP at 72 hours (3692 vs. 1516 in control), and the number of micronuclei in PCE observed in animals treated with BP was increased at both time points (44 and 46, respectively vs. 2 in control). Therefore, the test was valid.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
The test substance carbitol did not induce micronuclei formation in bone marrow PCE in mice. - Executive summary:
Male mice were treated intraperitoneally with 2 -(2 -ethoxyethoxy)ethanol for two consecutive days at 2ml/kg/day. A positive control group was given 100mg/kg benzopyrene. Analysis of PCE in bone marrow of animals at 48 hours and 72 hours demonstrated that the substance did not induce micronuclei whereas the number of micronuclei observed in positive control animals was increased at both time points.
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