Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-858-8 | CAS number: 75-29-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 91.5 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Dose descriptor starting point:
- NOAEC
- Value:
- 3 252 mg/m³
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 2 287.8 mg/m³
- Explanation for the modification of the dose descriptor starting point:
A NOAEC of 3252 mg/m³, resulting from a 90d inhalation exposure repeated dose toxicity study was considered for the derivation of the DNEL. This NOAEC was corrected for DNEL derivation by considering difference in daily exposure (6 h/d in study, 8 h/d for workers) and considering differences in respiratory volume between rats as used in study and workers performing lightweight activities in line with ECHA guidance for derivation of DNELs.
Worker – Inhalation = 3252 mg/m3 x 6/8 x 7/5 x 6.7/10 = 2287.8 mg/m3
- AF for dose response relationship:
- 1
- Justification:
- dose descriptor is a NOAEC from reliable study
- AF for differences in duration of exposure:
- 2
- Justification:
- sub-chronic to chronic assessment factor
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- rat - systemic effect (inhalation route) - not applicable for setting inhalation DNEL
- AF for other interspecies differences:
- 2.5
- Justification:
- systemic effect remaining differences according to guidance
- AF for intraspecies differences:
- 5
- Justification:
- workers default according to guidance
- AF for the quality of the whole database:
- 1
- Justification:
- good quality, subchronic data, supported by read-across reproductive data
- AF for remaining uncertainties:
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 132 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Dose descriptor starting point:
- NOAEC
- Value:
- 3 252 mg/m³
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 13 200 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
A NOAEC of 3252 mg/m³, resulting from a 90d inhalation exposure repeated dose toxicity study was considered for the derivation of the DNELdermal for workers. This NOAEC was corrected for DNEL derivation by considering difference in daily exposure (6 h/d in study, 8 h/d for workers) and considering conversion from NOAEC to NOAEL by multiplying with 0.29 m³/kg bw in line with ECHA guidance for derivation of DNELs and correcting by 100%/10% considering differences in absorption.
NOAEC of 3252 mg/m³ * 7/5 *(0.29 m³/kg bw) * 100%/10% = 13200 mg/m³ (corrected NOAEL dermal)
- AF for dose response relationship:
- 1
- Justification:
- dose descriptor is a NOAEL
- AF for differences in duration of exposure:
- 2
- Justification:
- sub-chronic to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- rat - systemic effect (dermal route)
- AF for other interspecies differences:
- 2.5
- Justification:
- systemic effect
- AF for intraspecies differences:
- 5
- Justification:
- workers
- AF for the quality of the whole database:
- 1
- Justification:
- good quality
- AF for remaining uncertainties:
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Additional information - workers
Acute DNELs:
Worker: Production of isopropyl chloride (IPC) is in excess of 10 t/y. According to REACh guidance “Guidance on Information Requirement and Chemical Safety Assessment Part B: Hazard Assessment”, above 10t/y, the establishment of acute toxicity DNEL is unnecessary in most cases, as the DNEL based on long-term exposure is normally sufficient to ensure that adverse effects do not occur. Thus, as long-term DNELs are available for IPC and this substance is not classified for acute toxicity via any route of exposure, separate acute DNELs were not derived. As IPC is not a skin irritant; for local effects the systemic DNEL may be used as default.
Long term DNELs:
DNELs are based on the inhalation rat study (key study selected) entitled "Inhalation Toxicity of Isopropyl Chloride: 90-Day Study on Rats". Starting Dose for DNEL Calculation = 996 ppm (NOAEC) = 3252 mg/m3 at 20 degrees Celsius and 1 atm.
Modified doses for DNEL Calculations:
Worker – Inhalation = 3252 mg/m3 x 6/8 x 7/5 x 6.7/10 = 2287.8 mg/m3
Worker – Dermal = 3252 mg/m3 x 7/5 x 0.29 m3/kg bw/d = 1320 mg/kg bw
Absorption: IPC is expected to be absorbed intact via all relevant routes of exposure [1, 2]. The low molecular weight (78.5413 g/mol), log POW value (1.9), and physical state of IPC favour its absorption via various routes of exposure (i.e., oral, dermal, and inhalation). The high vapour pressure of IPC, however, limits its absorption following dermal exposure, and renders inhalation the most relevant route of exposure. Based on this information and according to REACh guidance “Guidance on Information Requirement and Chemical Safety Assessment Part B: Hazard Assessment”, the oral, dermal, and inhalational absorption was determined to be 100%. Given the VP value of IPC, the dermal absorption was assessed to be 10%.
Modified doses for DNEL Calculations with Absorption Values:
Worker – Inhalation = 2287.8 mg/m3
Worker – Dermal = 1320 mg/kg bw x 10 = 13200 mg/kg bw
Assessment Factors (AF):
Worker – Inhalation = 2.5 (for non-metabolic species differences) x 5 for (intraspecies difference); no scaling factor required (as per REACh guidance) x 2 for duration from subchronic to chronic; no assessment factor for dose-response; no assessment factor for quality of database = 25
Worker – Dermal = 4 (rat scaling factor) x 2.5 (for non-metabolic species differences) x 5 for (intraspecies difference) x 2 for duration from subchronic to chronic; no assessment factor for dose-response; no assessment factor for quality of database = 100
Final DNELs:
Worker – Inhalation = 91.5 mg/m3
Worker – Dermal = 132 mg/kg bw
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 16.3 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 50
- Dose descriptor starting point:
- NOAEC
- Value:
- 3 252 mg/m³
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 813 mg/m³
- Explanation for the modification of the dose descriptor starting point:
A NOAEC of 3252 mg/m³, resulting from a 90d inhalation exposure repeated dose toxicity study was considered for the derivation of the DNEL. This NOAEC was corrected for DNEL derivation by considering difference in daily exposure (6 h/d in study, 24 h/d for general population) in line with ECHA guidance for derivation of DNELs.
NOAEC of 3252 mg/m³ * (6 h/d / 24 h/d) = 813 mg/m³ (corrected NOAEC)
- AF for dose response relationship:
- 1
- Justification:
- dose descriptor is a NOAEC
- AF for differences in duration of exposure:
- 2
- Justification:
- sub-chronic to chronic
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- rat - systemic effect (inhalation route)
- AF for other interspecies differences:
- 2.5
- Justification:
- systemic effect
- AF for intraspecies differences:
- 10
- Justification:
- general population
- AF for the quality of the whole database:
- 1
- Justification:
- good quality
- AF for remaining uncertainties:
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 47.2 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Dose descriptor starting point:
- NOAEC
- Value:
- 3 252 mg/m³
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 9 430 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
A NOAEC of 3252 mg/m³, resulting from a 90d inhalation exposure repeated dose toxicity study was considered for the derivation of the DNELdermal for workers. This NOAEC was corrected for DNEL derivation by considering difference in daily exposure (6 h/d in study, 24 h/d for general population) and considering conversion from NOAEC to NOAEL by multiplying with 1.15 m³/kg bw in line with ECHA guidance for derivation of DNELs (total factor of 0.29) in line with ECHA guidance for derivation of DNELs and correcting by 100%/10% considering differences in absorption.
NOAEC of 3252 mg/m³ * 0.29 m³/kg bw/d * 100%/10% = 9430 mg/kg bw/d (corrected NOAEL dermal)
- AF for dose response relationship:
- 1
- Justification:
- dose descriptor is a NOAEL corr.
- AF for differences in duration of exposure:
- 2
- Justification:
- sub-chronic to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- rat - systemic effect (dermal route)
- AF for other interspecies differences:
- 2.5
- Justification:
- systemic effect
- AF for intraspecies differences:
- 10
- Justification:
- general population
- AF for the quality of the whole database:
- 1
- Justification:
- good quality
- AF for remaining uncertainties:
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 4.7 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 943 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
A NOAEC of 3252 mg/m³, resulting from a 90d inhalation exposure repeated dose toxicity study was considered for the derivation of the DNELdermal for workers. This NOAEC was corrected for DNEL derivation by considering difference in daily exposure (6 h/d in study, 24 h/d for general population) and considering conversion from NOAEC to NOAEL by multiplying with 1.15 m³/kg bw in line with ECHA guidance for derivation of DNELs (total factor of 0.29).
NOAEC of 3252 mg/m³ * 0.29 m³/kg bw/d = 943 mg/kg bw/d (corrected NOAEL dermal)
- AF for dose response relationship:
- 1
- Justification:
- dose descriptor is a NOAEL
- AF for differences in duration of exposure:
- 2
- Justification:
- sub-chronic to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- rat - systemic effect (oral route)
- AF for other interspecies differences:
- 2.5
- Justification:
- systemic effect
- AF for intraspecies differences:
- 10
- Justification:
- general population
- AF for the quality of the whole database:
- 1
- Justification:
- good quality
- AF for remaining uncertainties:
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Additional information - General Population
Acute DNELs:
General Population: Production of isopropyl chloride (IPC) is in excess of 10 t/y. According to REACh guidance “Guidance on Information Requirement and Chemical Safety Assessment Part B: Hazard Assessment”, above 10t/y, the establishment of acute toxicity DNEL is unnecessary in most cases, as the DNEL based on long-term exposure is normally sufficient to ensure that adverse effects do not occur. Thus, as long-term DNELs are available for IPC and this substance is not classified for acute toxicity via any route of exposure, separate acute DNELs were not derived. As IPC is not a skin irritant; for local effects the systemic DNEL may be used as default.
Long term DNELs:
DNELs are based on the inhalation rat study (key study selected) entitled "Inhalation Toxicity of Isopropyl Chloride: 90-Day Study on Rats". Starting Dose for DNEL Calculation = 996 ppm (NOEC) = 3252 mg/m3
Modified doses for DNEL Calculations:
General Population – Oral = 3252 mg/m3 x 0.29 m3/kg bw/d = 943 mg/kg bw/day
General Population – Inhalation = 3252 mg/m3 x 6/24 = 813 mg/m3
General Population – Dermal = 1606 mg/m3 x 0.29 m3/kg bw/day = 943 mg/kg bw/day
Absorption: IPC is expected to be absorbed intact via all relevant routes of exposure [1, 2]. The low molecular weight (78.5413 g/mol), log POW value (1.9), and physical state of IPC favour its absorption via various routes of exposure (i.e., oral, dermal, and inhalation). The high vapour pressure of IPC, however, limits its absorption following dermal exposure, and renders inhalation the most relevant route of exposure. Based on this information and according to REACh guidance “Guidance on Information Requirement and Chemical Safety Assessment Part B: Hazard Assessment”, the oral and inhalational absorption was determined to be 100%. Given the VP value of IPC, the dermal absorption was assessed to be 10%.
Modified doses for DNEL Calculations with Absorption Values:
General Population – Oral = 943 mg/kg bw/day
General Population – Inhalation = 813 mg/m3
General Population – Dermal = 943 mg/kg bw/day x 10 = 9430 mg/kg bw/day
Assessment Factors (AF):
General Population – Oral = 4 (rat scaling factor) x 2.5 (for non-metabolic species differences) x 10 for (intraspecies difference) x 2 for duration from subchronic to chronic; no assessment factor for dose-response; no assessment factor for quality of database = 200
General Population – Inhalation = 2.5 (for non-metabolic species differences) x 10 for (intraspecies difference); no scaling factor required (as per REACh guidance) x 2 for duration from subchronic to chronic; no assessment factor for dose-response; no assessment factor for quality of database = 50
General Population – Dermal = 4 (rat scaling factor) x 2.5 (for non-metabolic species differences) x 10 for (intraspecies difference) x 2 for duration from subchronic to chronic; no assessment factor for dose-response; no assessment factor for quality of database = 200
Final DNELs:
General Population – Oral = 4.7 mg/kg bw
General Population – Inhalation = 16.3 mg/m3
General Population – Dermal = 47.2 mg/kg bw
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.