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Diss Factsheets
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EC number: 201-607-5 | CAS number: 85-44-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- other: ES-80-M-6
- Principles of method if other than guideline:
- Method is following the procedures described in the MIC Environmental Assessment Method for Conducting Acute Toxicity Tests with
Daphnia magna (Grueber and Adams, 1980) Environmental Sciences Report ES-80-M-6), and
Methods for Acute Toxicity Tests with fish, macroinvertebrates and amphibians (U.S. EPA (1975) EPA 660/3-75-009). - GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- >= 640 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 640 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Executive summary:
A test on the acute toxicity to Daphnia magna was performed for phthalic acid according to "Methods for Acute Toxicity Tests" with fish, macroinvertebrates and amphibians of the US EPA. For a test period of 48 hours an EC50 value of > 640 mg/l was obtained (Adams, 1986).
Reference
RM-Freetext:
The original pH of the 640 mg/l stock solution was 3.01 and afterwards raised with NaOH.
Description of key information
A test with respect to the acute toxicity towards invertebrates (Daphnia magna) using the hydrolysis product phthalic acid as test substance is taken into account to describe the hazardous potential of phthalic anhydride towards aquatic invertebrates. An 48 h-EC50 of > 640 mg/l was determined in this test. (Adams, 1986)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 640 mg/L
Additional information
Concerning the toxicity with Daphnia magna there is only one test with phthalic anhydride available, but should not be used for the hazard assessment, due to missing information on pH. In comparison to the result found by Adams, 1986, where the hydrolysis product phthalic acid was used as test substance in a buffered medium, it cannot be excluded that the toxicity observed was due to pH effects. The study is stated to be reliable, but should not be used for the hazard assessment. In order to draw a conclusion on toxicity towards aquatic invertebrates for phthalic anhydride, the test on the acute toxicity to Daphnia magna with phthalic acid is taken into account. The study was performed according to “Methods for Acute Toxicity Tests” with fish, macroinvertebrates and amphibians of the US EPA. For a test period of 48 hours an EC50 value of > 640 mg/l was obtained (Adams, 1986).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.