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EC number: 469-910-7 | CAS number: 847842-48-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
Description of key information
For the following reasons, no determination was possible by Method C19 of Commission Directive 2001/59/EC (which constitutes Annex V of Council Directive 67/548/EEC).
The method guideline states that the measurement of adsorption coefficient should be carried out on substances in their ionised and unionised forms.
The test material is a salt and is made up of two components, abacavir and glutaric acid.
The abacavir component has predicted dissociation constants of 14.86, 6.53 and -3.38 using ACD/pKa 8.03.
The glutaric acid component has an experimental database match for dissociation constants of 5.50 and 4.39 using ACD/pKa DB 8.02.
Based on this information, this suggests that the abacavir component would be unionised between approximately 7.5 and 13.5. The glutaric acid component is unionised below approximately 3.5. As the pH of sewage treatment plants operate between pH 5.5 and 7.5 and the environmentally relevant range is between approximately 5.5 and 8.5, testing is usually conducted in the latter range. However, the test material is a salt containing amine groups. Experience has shown that positively charged nitrogens can interact with the column stationary phase by forces other than partitioning.
Key value for chemical safety assessment
Additional information
The method guideline states that the measurement of adsorption coefficient should be carried out on substances in their ionised and unionised forms.
The test material is a salt and is made up of two components, abacavir and glutaric acid.
The abacavir component has predicted dissociation constants of 14.86, 6.53 and -3.38 using ACD/pKa 8.03.
The glutaric acid component has an experimental database match for dissociation constants of 5.50 and 4.39 using ACD/pKa DB 8.02.
Based on this information, this suggests that the abacavir component would be unionised between approximately 7.5 and 13.5. The glutaric acid component is unionised below approximately 3.5. As the pH of sewage treatment plants operate between pH 5.5 and 7.5 and the environmentally relevant range is between approximately 5.5 and 8.5, testing is usually conducted in the latter range. However, the test material is a salt containing amine groups. Experience has shown that positively charged nitrogens can interact with the column stationary phase by forces other than partitioning.
Determinations were performed in order to obtain evidence which supported the unsuitability of the HPLC method. The method used was to predominately analyse the abacavir component within the test material in the presence of glutaric acid. It is probable that using the HPLC conditions specified in the guidelines, the glutaric acid component would not be detected at the wavelength selected. Adjusting the pH of the mobile phase to approximately 8.5 would suggest that testing would be performed with the abacavir component in its unionised form, whereas adjusting the pH to approximately 5 would ionise the amine groups within the test material. No alteration to the ionisation of the glutaric acid component would occur between the two pHs. No difference in the retention time was observed between the two pHs. Adjusting the pH of the mobile phase to approximately 3 had no further effect on the ionisation of the abacavir component from the pH5 determination. However, the elution time was considerably reduced to the dead-time of the column. At this pH, and on condition that it could be detected, the acid component should also be retained. The difference in the results was concluded to be due to test material interaction with the stationary phase by forces other than partitioning. At pH 3, the free silanols on the column were saturated with acidic hydrogens leaving only a small proportion of ionic bonding to occur. Hence, the test material eluted quickly. However, at pH 5, the stationary phase had significantly more free silanols available for interaction hence the significantly increased retention. Quantitative Structure Activity Relationships (QSAR'S) detailed in the Technical Guidance Document (TGD) can be unreliable and therefore were not used in the estimation of adsorption coefficient. Although correction factors can be applied, it has been shown that QSAR models can significantly under estimate the adsorption coefficient of ionic substances. Therefore, due to the unsuitability of the HPLC method and the QSAR assessment, and estimation was performed using specialist chemical estimation software.
Using fragment constant methodology, the log10 Koc value for the test of the test material has been estimated. The results are shown in the following table:
Component |
PCKOCWIN Log10Koc |
Abacavir |
1.80 |
Glutaric Acid |
1.07 |
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