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EC number: 265-196-4 | CAS number: 64742-93-4 A complex black solid obtained by blowing air through a heated residuum, or raffinate from a deasphalting process with or without a catalyst. The process is principally one of oxidative condensation which increases the molecular weight.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Several studies in populations of exposed roofing workers are available. These include epidemiological studies, biomarker exposure studies and genotoxicity assays in exposed workers.
Additional information
Exposure related observations in humans
Oxidized Asphalt - DNA Damage
The potential for exposure to oxidized asphalt and it’s emissions to cause DNA damage has been investigated in a small number of occupational studies in asphalt roofing workers (Fuchs et al., 1996, Toraason et al., 2001). These studies monitored workers for the incidence of DNA strand breaks and/or non-specific oxidative damage (8-oxo-dG), primarily in peripheral lymphocytes, following exposure to oxidized asphalt emissions evolved at high temperatures (> 350ºC).
Both studies suffered from investigating effects in only very small sample sizes (seven workers). In addition the Fuchs study had poorly matched controls, incomplete and inconsistent reporting of data and did not control for the effects of smoking.
The Fuchs study showed an increased incidence of DNA strand breaks in the small group of asphalt roofing workers. The conclusions that can be reached from this work are limited however due to the methodological problems. In the study by Toraason and co-workers a small increase in the incidence of DNA strand breaks was reported but there was no effect on non-specific oxidative damage. Methodological problems also limit the conclusions that can be drawn from this study.
In conclusion, the results of two limited occupational studies in asphalt roofing workers show no clear evidence that exposure to oxidized asphalt or it’s emissions causes DNA damage.
Exposure Studies in Roofing Workers
Three studies were identified which used biomarkers ( adduct formation and urinary PAH metabolites) to investigate exposure and uptake in roofing workers. Although results confirmed exposure, the applicability of these studies is limited due to methodological deficiencies and possible confounding exposure to coal-tar.
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