Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 266-047-6 | CAS number: 65997-18-4 Frit is a mixture of inorganic chemical substances produced by rapidly quenching a molten, complex combination of materials, confining the chemical substances thus manufactured as nonmigratory components of glassy solid flakes or granules. This category includes all of the chemical substances specified below when they are intentionally manufactured in the production of frit. The primary members of this category are oxides of some or all of the elements listed below. Fluorides of these elements may also be included in combination with these primary substances.@Aluminum@Manganese@Antimony@Molybdenum@Arsenic@Neodymium@Barium@Nickel@Bismuth@Niobium@Boron@Phosphorus@Cadmium@Potassium@Calcium@Silicon@Cerium@Silver@Chromium@Sodium@Cobalt@Strontium@Copper@Tin@Gold@Titanium@Iron@Tungsten@Lanthanum@Vanadium@Lead@Zinc@Lithium@Zirconium@Magnesium
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-guideline experimental study, published in peer reviewed literature, minor restrictions in design and/or reporting but otherwise adequate for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Five week old female Wistar rats were used in this balance, excretion and tissue distribution study. Two groups of seven rats (one control and one experimental) were fed either a control diet or a control plus sodium metavanadate diet (100 ppm) for 7 days.
- GLP compliance:
- not specified
Test material
- Details on test material:
- - Name of test material (as cited in study report): Sodium metavanadate (V+5)
- Molecular formula (if other than submission substance): NaVO3
- Purchased from: Wako Pure Chem. Ind. Ltd. Japan
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Japan SLC Inc, Shizouka Japan
- Age at study initiation: Approx 5 weeks
- Weight at study initiation: 110 to 120 g
- Fasting period before study: none
- Housing: metabolic cages
- Individual metabolism cages: yes
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- other: Control diet
- Details on exposure:
- The animals were fed ad libitum the control diet with and without sodium vanadate (100ppm) for one week. The control diet was bought from Oriental Co., Japan and it had the following composition based on 100g of diet: Protein 24.6g, Fat 5.6g, Carbohydrate 52.8g, Cellulose 3.1g, Calcium 1.15g, Phosphorus 0.88g, Magnesium 0.25g, Sodium 0.26g, Potassium 0.89g, Iron 12.3mg, Vitamin B1 2.04mg, Vitamin B2 1.21mg, Vitamin B6 0.92mg, Niacin 9.68mg, Pantothenic acid 3.05mg, Folic acid 0.15mg, Choline 0.23g, Inositol 433mg, Vitamin A 1810 IU, Vitamin D3 80 IU, Vitamin E 10.4mg.
The vanadium content of the control diet was 0.32ppm. - Duration and frequency of treatment / exposure:
- The duration of exposure was one week and this was done via the diet at libitum.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100ppm in the diet.
- No. of animals per sex per dose / concentration:
- Seven female Winstar rats for the control and the exposed group
- Control animals:
- yes, concurrent vehicle
- Positive control reference chemical:
- No data
- Details on study design:
- No data
- Details on dosing and sampling:
- PHARMACOKINETIC STUDY (Absorption, distribution, excretion)
- Tissues and body fluids sampled (delete / add / specify): urine, faeces, liver, kidney, heart, lung, brain, thymus, spleen, muscle, intestine, stomach, femur and tibia
- Time and frequency of sampling: urine and faeces was collected daily during feeding. The other tissues / organ was collected at the end of the study.
Determination of vanadium in tissues was conducted using an atomic absorption spectrophotometer with a graphic furnace atomizer and in feces and urine directly by flameless atomich absorption spetrophotometry. - Statistics:
- Values were reported as means SEM and the data were analysed using one-way ANOVA or by a Student-Newman-Keul test.
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- Absorption of vanadium was calculated to be 1168 µg/kg/d (16.5%) of the total daily intake of 7060 ± 574 µg/kg/d.
- Type:
- distribution
- Results:
- The majority of the vanadium distribution was found in the femur, tibia, kidney, spleen and intestine of the experimental group. The tibia had levels of 1.84 µg/g. In the control group the highest vanadium levels were found in the lung (0.13 µg/g).
- Type:
- excretion
- Results:
- The percentages excreted in the urine and feces were 0.86% and 83.5% of the intake (7060 µg/kg/d) respectively.
- Type:
- other: Retention
- Results:
- The retention was 15.7 %
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Absorption was calculated to be about 16.5%.
- Details on distribution in tissues:
- The highest vanadium distribution was found in the tibia (1.84 µg/g), and the lowest was found in the brain (0.13 µg/g). In the control group the highest vanadium levels were found in the lung.
- Details on excretion:
- The percentages excreted in the urine and faeces were 0.86% and 83.5% of the intake (7060 µg/kg/d, as vanadium) respectively.
Metabolite characterisation studies
- Metabolites identified:
- no
Any other information on results incl. tables
The recovery of added vanadium in various tissues were from 96.7 to 109.3% with a maximum coefficient of variation of 8.6%.
Applicant's summary and conclusion
- Conclusions:
- The absorption of vanadium was calculated to be 1168 ± 519 µg/kg/d (16.5%) of the total daily intake of 7060 ± 574 µg/kg/d. The results also indicate that the majority of the vanadium was distributed in the femur, tibia, kidney, spleen and intestine for the experimental group. The tibia had levels of 1.84 µg/g. In the control group the highest vanadium levels were found in the lung (0.13 µg/g). Excretion levels / percentages in the urine and faeces were 0.86% and 83.5% of the intake (7060 µg/kg/d) respectively and the retention was 15.7 % of total intake.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)
Ačkoli agentura ECHA poskytuje on-line velké množství materiálů ve vašem jazyce, část této stránky je bohužel k dispozici pouze v angličtině. Další podrobností o postupu agentury ECHA při zveřejňování informací v různých jazycích.
Vítejte na internetových stránkách agentury ECHA. Tyto stránky nejsou plně podporované v prohlížeči Internet Explorer 7 (a starších verzích). Aktualizujte si prohlížeč Internet Explorer na novější verzi.
Tato webová stránka používá cookies, aby se vám naše stránky používaly co nejlépe.
Více informací o tom, jak používáme soubory cookies.