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EC number: 234-933-1 | CAS number: 12042-91-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test method described in detail, no GLP and no detailed information on test substance.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
- Deviations:
- yes
- Remarks:
- range finding test
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- other: Eisenia andrei
- Animal group:
- annelids
- Details on test organisms:
- Age: 9-12 weeks old with a well-developed clitellum
Starting weight: 259 - 529 mg - Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- no
- Total exposure duration:
- 18 d
- Test temperature:
- 20 ± 2 °C
- pH:
- nominal pH (KCl): 3.5, 5.0 and 7.0
measured pH (KCl): 3.24±0.10, 4.86±0.54 and 7.22±0.17 - Moisture:
- 55% (w/w)
- Details on test conditions:
- Test soils: artificial soil according to OECD (1984)
Number of replicates / conc: 1
Test container: 1 L glass test containers with 400 g dry soil
Organisms per container: 10
Light: continuous illumination (400 lux)
TEST PARAMETER
Mortality and reproduction - Nominal and measured concentrations:
- nominal: 0, 10, 100, 1000 and 4000 mg Al/kg dw
- Reference substance (positive control):
- no
- Duration:
- 18 d
- Dose descriptor:
- LC50
- Effect conc.:
- 457 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- other: Al
- Basis for effect:
- mortality
- Remarks on result:
- other: 95% CI: 286-729 mg Al/kg dw; pH (KCl) 3.24±0.10
- Duration:
- 18 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 4 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- other: Al
- Basis for effect:
- mortality
- Remarks on result:
- other: pH (KCl) 4.86±0.54
- Duration:
- 18 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 4 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- other: Al
- Basis for effect:
- mortality
- Remarks on result:
- other: pH (KCl) 7.22±0.17
- Duration:
- 18 d
- Dose descriptor:
- EC50
- Effect conc.:
- 330 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- other: Al
- Basis for effect:
- reproduction
- Remarks on result:
- other: pH (KCl) 3.24 ± 0.10
- Duration:
- 18 d
- Dose descriptor:
- EC50
- Effect conc.:
- 197 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- other: Al
- Basis for effect:
- reproduction
- Remarks on result:
- other: 95% CI: 8.3-4661 mg Al/kg dw; pH (KCl) 4.86±0.54
- Duration:
- 18 d
- Dose descriptor:
- EC50
- Effect conc.:
- 883 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- other: Al
- Basis for effect:
- reproduction
- Remarks on result:
- other: 95% CI: 209-3722 mg Al/kg dw; pH (KCl) 7.22±0.17
- Reported statistics and error estimates:
- Trimmed Spearman-Karber method
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Mortality increased with decreasing pH level, reproduction was lowest at a nominal pH level of 5.0.
- Executive summary:
This eartchworm toxicity test was similar to an OECD guideline 207, on Eisenia andrei. The test ran for 18 days and was not performed under GLP. The tested concentrations were : 0, 10, 100, 1000 and 4000 mg Al/kg soil dw. Aluminium sulphate and aluminium chloride were tested in this test. pH levels decreased when aluminium concentration increased.
The results obtained are the following :
18 d-LC50 (mortality)= 457 mg/kg soil dw (95% CI: 286-729 mg Al/kg dw; pH (KCl) 3.24 ± 0.10)
18 d-LC50 > 4000 mg/kg soil dw (pH (KCl) 4.86 ± 0.54)
18 d-LC50 > 4000 mg/kg soil dw (pH (KCl) 7.22 ± 0.17)
18 d-EC50 (reproduction) = 330 mg Al/kg soil dw (pH (KCl) 3.24 ± 0.1)
18 d-EC50 (reproduction) =197 mg Al/kg soil dw (95 % CI : 8.3 - 4661 kg Al/kg soil dw, pH (KCl) 4.86 ± 0.54)
18 d-EC50 (reproduction) =883 mg Al/kg soil dw (95 % CI : 209 - 3722 mg Al/kg soil dw, pH (KCl) 7.22 ± 0.17).
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test method described in detail, no GLP and no detailed information on test substance.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
- Deviations:
- yes
- Remarks:
- range finding test
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- other: Eisenia andrei
- Animal group:
- annelids
- Details on test organisms:
- Age: 9-12 weeks old with a well-developed clitellum
Starting weight: 259 - 529 mg - Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- no
- Total exposure duration:
- 14 d
- Test temperature:
- 20 ± 2 °C
- pH:
- nominal pH (KCl): 3.5, 5.0 and 7.0
measured pH (KCl): 3.21-3.52, 3.69-4.38 and 4.37-6.70 (lowest pH value measured at the highest aluminium concentration) - Moisture:
- 55% (w/w)
- Details on test conditions:
- Test soils: artificial soil according to OECD (1984)
Number of replicates / conc: 1
Test container: 1 L glass test containers with 400 g dry soil
Organisms per container: 10
Light: continuous illumination (400 lux)
TEST PARAMETER
Mortality - Nominal and measured concentrations:
- nominal: 0, 10, 100 and 1000 mg Al/kg dw
- Reference substance (positive control):
- no
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- 316 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- other: Al
- Basis for effect:
- mortality
- Remarks on result:
- other: pH (KCl) 3.21-3.52
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- 359 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- other: Al
- Basis for effect:
- mortality
- Remarks on result:
- other: 95% CI: 274-471 mg Al/kg dw; pH (KCl) 3.69-4.38
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- other: Al
- Basis for effect:
- mortality
- Remarks on result:
- other: pH (KCl) 4.37-6.70
- Details on results:
- pH levels decreased with increasing aluminium concentrations.
- Reported statistics and error estimates:
- Trimmed Spearman-Karber method
- Validity criteria fulfilled:
- not specified
- Executive summary:
This acute eartchworm toxicity test was similar to an OECD guideline 207, on Eisenia andrei. The test ran for 14 days and was not performed under GLP. The tested concentrations were : 0, 10, 100 and 1000 mg Al/kg soil dw. Aluminium sulphate and aluminium chloride were tested in this test. pH levels decreased when aluminium concentration increased.
The results obtained are the following :
14 d-LC50 = 316 mg/kg soil dw (pH KCl = 3.21 - 3.52)
14 d-LC50 = 359 mg/kg soil dw (95 % CI : 274 - 471 mg Al/ kg soil dw)
14 d-LC50 > 1000 mg/kg soil dw (pH KCl = 4.37 - 6.70).
Referenceopen allclose all
Description of key information
Similar to OECD guideline 207, not GLP, key study, validity 2 (van Gestel, 2001, aluminium chloride and aluminium sulphate):
18 d-LC50 = 457 mg/kg soil dw (95 % CI : 286 - 729 mg AI/kg dw, pH (KCl) 3.24 +- 0.1)
18 d-LC50 > 4000 mg/kg soil dw (pH (KCl) 4.86 +-0.54)
18 d-LC50 > 4000 mg/kg soil dw (pH (KCl) 7.22 +- 0.17)
18 d-EC50 (reproduction) = 330 mg/kg soild dw (pH (KCl) 3.24 +- 0.1)
18 d-EC50 (reproduction) = 197 mg/kg soil dw (95 % CI : 8.3 - 4661 mg AI/kg soil dw)
18 d-EC50 (reproduction) = 883 mg/kg soil dw (95 % CI : 209 - 3722 mg AI/kg soil dw)
Similar to OECD guideline 207, not GLP, key study, validity 2 (van Gestel, 2001, aluminium chloride hexahydrate):
14 d-LC50 = 359 mg/kg soil dw (95 % CI = 274 - 471 mg Al/kg soil dw)
14 d-LC50 = 316 mg/kg soil dw (pH KCl = 3.21 - 3.52)
14 d-LC50 > 1000 mg/kg soil dw (pH KCl = 4.37 - 6.70)
Key value for chemical safety assessment
- Long-term EC10, LC10 or NOEC for soil macroorganisms:
- 197 mg/kg soil dw
Additional information
Two studies simillar to OECD guideline 207 are available to assess the toxicity to soil macroorganisms except arthropods. One was performed on aluminium chloride and aluminium sulphate while the other one was performed on aluminium chloride hexahydrate. The lowest EC50 obtained was 197 mg/kg soil dw (95 % CI : 8.3 - 4661 mg AI/kg soil dw) based on reproduction of Eisenia andrei exposed to aluminium chloride or aluminium sulphate. The lowest LC50 was 316 mg/kg soil dw (pH KCl = 3.21 - 3.52) based onEisenia andreimortality on a 14 days period.
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