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EC number: 219-785-8 | CAS number: 2530-85-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- Detail missing on animals and environmental conditions.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-trimethoxysilylpropyl methacrylate
- EC Number:
- 219-785-8
- EC Name:
- 3-trimethoxysilylpropyl methacrylate
- Cas Number:
- 2530-85-0
- Molecular formula:
- C10H20O5Si
- IUPAC Name:
- 3-trimethoxysilylpropyl methacrylate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories (Kingston, NY)
- Age at study initiation: ca. 6 weeks
- Housing: Stainless steel cages, with wire floors
- Diet: Agway certified rodent chow
- Water: provided by an automatic water system
- Acclimation period: 2 weeks
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: distilled water adjusted to pH4 with acetic acid
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure chamber volume: 120 liters
- System of generating particulates/aerosols: Four solo-sphere nebulizers containing a 15% (w/w) solution of 3-(trimethoxysilyl)propyl methacrylate (in distilled water, adjusted to pH 4 with acetic acid) were connected to 2 large triple-necked flasks (to trap large liquid droplets) which were, in turn, connected to the exposure chamber. Dried air was passed into each nebulizer, operating at a pressure of 20 p.s.i, and the resulting aerosol conducted into the animal chamber.
- Method of particle size determination: One sample of chamber atmosphere was analysed for particle size. A 3 minute flow of air at 10 l/min was conducted through a Sierra Cascade Inspector. Particles were collected on 3 stages of glass fibre filters. Several chamber air samples were subjected to gas chromatographic analysis to determine methanol concentration.
TEST ATMOSPHERE
- Brief description of analytical method used: Every 30 minutes during exposure, a sample of chamber atmosphere was drawn through a tared fiberglass filter at the rate of 2.2 l/min. After 2 min the filter was removed, dried in a drying overn to a constant weight and the final weight recorded. The change in weight represented the amount of hydrolysed silane collected. According to the sponsor, this represents ca. 72.17% of the test substance. This factor, along with the volume of air sampled, was used to calculate the concentration of test substance in the chamber air.
- Samples taken from breathing zone: yes
VEHICLE
- Composition of vehicle (if applicable): distilled water
- Concentration of test material in vehicle (if applicable): Distilled water was adjusted to pH 4 with acetic acid and used to make a 15% solution of test substance. - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- GC
- Duration of exposure:
- 4 h
- Concentrations:
- 2.28 mg/L
- No. of animals per sex per dose:
- 5 males, 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The animals were weighed just before exposure and at 7 and 14 days after exposure. All rats were observed frequently on the day of the test and daily during the subsequent observation period.
- Necropsy of survivors performed: yes - Statistics:
- No statistical analysis was included in the report.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2.28 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- There were no deaths.
- Clinical signs:
- other: During exposure, a dense fog was present in the animal chamber, preventing observation of the test rats. After exposure, slow righting reflex and laboured breathing were apparent. At one day, the animals were fully recovered.
- Body weight:
- All animals gained weight.
- Gross pathology:
- No remarkable gross pathologic findings were seen.
- Other findings:
- None reported.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute inhalation toxicity study, conducted in a similar manner to OECD 403 but pre-GLP, an LC50 value of >2.28 mg/l (aerosol exposure) was determined.
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