Registration Dossier
Registration Dossier
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EC number: 203-740-4 | CAS number: 110-15-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The toxicokinetic behaviour of succinic acid was estimated from available data for the purpose of registration of the substance.
Absorption, distribution: No systemic effects were observed in the acute oral toxicity studies even at high doses. Only unspecific systemic effects (reduced body weight, emaciation) were detected in the repeated dose studies at high doses. Therefore it is concluded that an absorption after peroral administration of the submitted substance takes place, at least at high doses. No information on the distribution was obtained, as only unspecific effects were noted.
The logPow is very low (-0.59) and together with the acidic groups of the molecule does not favour an oral or an inhalation absorption of the substance, whereas the low molecular mass of 118 would point to a better absorption. An inhalation absorption is probably of low relevance because of the low vapour pressure of 0.000025 Pa.
Metabolism:
Succinic acid is an element of the citric acid cycle and is metabolised to fumaric acid.
No relevant differences occurred in the mutagenicity studies with and without the addition of a metabolising system. Therefore no indication of the importance of the metabolism of the test substance was obtained from these studies.
Bioaccumulation: A potential for bioaccumulation is unlikely, based on the low partition coefficient. No statement on the bioaccumulation can be derived from the comparison of the effective doses in the acute and the repeated dose oral toxicity study, when also considering the different extent of the investigations in both studies.
Excretion: No relevant data are available, which provide evidence on the route of excretion.
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