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Diss Factsheets
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EC number: 234-364-9 | CAS number: 11120-25-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Insufficient information provided on methods and results to accurately evaluate the study; no guideline available.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Distribution of Tungsten in the Rat Following Ingestion of Tungsten Compounds.
- Author:
- Kinard FW and Aull JC.
- Year:
- 1 945
- Bibliographic source:
- Journal of Pharmacology And Experimental Therapeutics, Vol. 83, Issue 1, 53-55.
Materials and methods
- Objective of study:
- distribution
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Distribution of tungsten in various organs of the rat following oral ingestion of tungsten compounds.
- GLP compliance:
- no
Test material
- Reference substance name:
- Ammonium wolframate
- EC Number:
- 234-364-9
- EC Name:
- Ammonium wolframate
- Cas Number:
- 11120-25-5
- Molecular formula:
- (NH4)10H2W12O42*4H2O
- IUPAC Name:
- Ammonium (para)tungstate
- Reference substance name:
- Ammonium paratungstate
- IUPAC Name:
- Ammonium paratungstate
- Details on test material:
- - Name of test material (as cited in study report): Ammonium paratungstate
Constituent 1
Constituent 2
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Thirty-seven day old rats were placed on a basal diet of ground purina dog chow in which the finely ground tungsten compounds had been incorporated. For each experimental diet, 2 female and 2 male rats were used with the sexes separately caged. Diet and water were given ad libitum.
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- For each experimental diet, 2 female and 2 male rats were used.
- Duration and frequency of treatment / exposure:
- Approximately 100 days.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Diet D: 0.6912 percent Ammonium paratungstate (0.5 per cent W) in Purina dog chow.
- No. of animals per sex per dose / concentration:
- 2 females and 2 males
- Control animals:
- yes, concurrent no treatment
- Positive control reference chemical:
- no
- Details on study design:
- The tissues of both rats of each sex on the same diet were combined, weighed, rinsed free of blood, and prepared for analysis. The method of Aull and Kinard was used for the determination of the tungsten.
- Details on dosing and sampling:
- PHARMACOKINETIC STUDY (Absorption, distribution, excretion)
- Tissues and body fluids sampled: brain, heart, uterus, lung, muscle, testis, blood, kidney and liver - Statistics:
- no data
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on distribution in tissues:
- No traces of tungsten were found in the heart, uterus, or brain of females. A trace amount of tungsten was found in the brain of males. No relation was observed between diet or sex and the presence or absence of tungsten in the lungs, muscle, or testis. Trace amounts of tungsten were found in the blood and liver of both male and female rats, and kidneys of male rats and 2 mgm of tungsten was found in the kidneys of female rats. Nine and 10 mgm percent tungsten was found in the bone of male and female rats respectively. Two and 9 mgm weight tungsten was found in the skin of male and female rats respectively. Trace amounts of tungsten were found in the male spleen while 10 mgm where found in the female spleen.
Metabolite characterisation studies
- Metabolites identified:
- not measured
Any other information on results incl. tables
In no instance was there any trace of tungsten found in the animals kept on the control diet.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.