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Diss Factsheets
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EC number: 203-905-0 | CAS number: 111-76-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Biotransformation and kinetics
Administrative data
- Endpoint:
- biotransformation and kinetics
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- - Principle of test:
Quantification of metabolites formed during degradation of 2-butoxyethanol
- Short description of test conditions: 3hrs exposure, then collection of metabolites by solvent extraction
- Parameters analysed / observed: Analysis of metabolites by GC-MS. - GLP compliance:
- not specified
- Type of medium:
- aquatic
Test material
- Reference substance name:
- 2-butoxyethanol
- EC Number:
- 203-905-0
- EC Name:
- 2-butoxyethanol
- Cas Number:
- 111-76-2
- Molecular formula:
- C6H14O2
- IUPAC Name:
- 2-butoxyethanol
Constituent 1
Results and discussion
- Transformation products:
- yes
Identity of transformation productsopen allclose all
- No.:
- #1
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- butoxyacetic acid
- No.:
- #2
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- butan-1-ol
- Inventory number:
- InventoryMultipleMappingImpl [inventoryEntryValue=EC 200-751-6]
- CAS number:
- 71-36-3
- Identity:
- 1-Butanol
- Molecular formula:
- C4H10O
- Molecular weight:
- 74.122
- SMILES notation:
- CCCCO
- InChl:
- InChI=1/C4H10O/c1-2-3-4-5/h5H,2-4H2,1H3
- No.:
- #3
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- sodium butyrate
- Inventory number:
- InventoryMultipleMappingImpl [inventoryEntryValue=EC 205-857-6]
- CAS number:
- 156-54-7
- Identity:
- Butanoic acid, sodium salt
- Molecular formula:
- C4H8O2.Na
- Molecular weight:
- 110.087
- SMILES notation:
- [Na+].CCCC(=O)[O-]
- InChl:
- InChI=1/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1
Any other information on results incl. tables
As well as the transformation products, unchanged 2 -butoxyethanol was also detected.
This study was part of a larger study that examined the potential of 11 bacterial strains to degrade 2 -butoxyethanol. This particular species/strain grew the fastest and tolerated the highest substrate concentrations among the strains/species examined (and hence why it was used for this metabolite study). The maximum growth rate was 0.645 h-1 at a concentration of 5 mM (590mg/L), which was completely degraded within less than 6 h. A stable degradation of 2-BE could be achieved for concentrations of up to 30 mM (3540mg/L). Beyond that value, 2 -butoxyacetic acid
accumulated and the pH decreased to 6, inhibiting further growth.
.Applicant's summary and conclusion
- Executive summary:
In a study that qualitatively measured the metabolites produced by bacterial degradation of 2 -butoxethanol, the bacterial strain Pseudomonas vancouverensis was found to produce the metabolites 2 -butoxyacetic acid, butanol and butanoic acid. These findings support the hypothesis that 2 -butoxyethanol degradation by bacteria in the environment proceeds by initial oxidation to 2 -butoxyacetic acid (as in mammals) followed by cleavage of the ether group to produce butanol and butanoic acid. The maximum growth rate was 0.645 h-1 at a concentration of 5 mM (590mg/L), which was completely degraded within less than 6 h. A stable degradation of 2-BE could be achieved for concentrations of up to 30 mM (3540mg/L).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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