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EC number: 237-523-0 | CAS number: 13825-74-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991-02-08 to 1991-03-07
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study reliable without restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Version / remarks:
- 1983
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- The study report states that the study was conducted in compliance with OECD Principles of Good Laboratory Practice (Bundesanzeiger Nr. 42a, of the 2nd of March 1983 and Bundesgesetzblatt, Part I, of the 22nd of March 1990.
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Titanium oxide sulphate
- EC Number:
- 237-523-0
- EC Name:
- Titanium oxide sulphate
- Cas Number:
- 13825-74-6
- Molecular formula:
- O5STi
- IUPAC Name:
- Titanium(IV) Oxysulfate
- Reference substance name:
- oxotitanium; sulfuric acid
- IUPAC Name:
- oxotitanium; sulfuric acid
- Details on test material:
- - Name of test material (as cited in study report): Titanylsulfate
- Physical state: brown liquid
- Storage condition of test material: refrigerator
- Stability under test conditions: The batch used was analysed prior to the study initiation and approved for use during the test period. A stability test in the solvent did not detect a relevant change in the percent active ingredient.
No further details were stated.
Constituent 1
Constituent 2
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Additional strain / cell type characteristics:
- other: histidine deficiant, ampicillin resistant, crystal-violet sensitiv, UV sensitiv
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 mix
- Test concentrations with justification for top dose:
- Range finding dose: 5000, 1000, 200 , 40, 8 µg/plate
Doses: 4800, 2400, 1200, 600, 300, 150 and 75 µg/plate - Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: methanol
Controlsopen allclose all
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- sodium azide
- Remarks:
- TA 1535
Migrated to IUCLID6: 10 µg
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: 0.2 µg nitrofurantoin
- Remarks:
- TA 100
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: 10 µg 4-nitro-1,2-phenylene diamine
- Remarks:
- TA 1537
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: 0.5 µg 4-nitro-1,2-phenylene diamine
- Remarks:
- TA 98
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: 3 µg 2-aminoanthracene
- Remarks:
- promutagen reverts all strains and serves as control for activating effect of S9 mix
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: in agar (plate incorporation)
DURATION
- Exposure duration: 48 h
NUMBER OF REPLICATIONS: 4
DETERMINATION OF CYTOTOXICITY
- Method: gross appraisal of background growth, marked and dose-dependent reduction in mutant count per plate compared to negative controls, titer determination - Evaluation criteria:
- criteria for positive result is a reproducible and dose-related increase in mutant counts of at least one strain: for TA 1535, TA 100, TA 98 increase about twice the amount of negative controls, respectively for TA 1537 threefold. Otherwise the result is negative.
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Results show that the test substance has neither a cytotoxic nor a genotoxic effect under the given test conditions. - Executive summary:
The purpose of the study was to evaluate the potential of test item titanium oxide sulphate for inducing bacterial reverse mutation. The study followed the protocol as given by OECD Guideline 471 (Ames Test). Test concentrations applied were 4800, 2400, 1200, 600, 300, 150 and 75 µg/plate. Results show that the test substance has neither a cytotoxic nor a genotoxic effect under the given test conditions. Reliabl result, as all controls reported to be valid.
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