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Diss Factsheets
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EC number: 204-589-7 | CAS number: 122-99-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- GLP was not compulsory at the time the study was performed
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-phenoxyethanol
- EC Number:
- 204-589-7
- EC Name:
- 2-phenoxyethanol
- Cas Number:
- 122-99-6
- Molecular formula:
- C8H10O2
- IUPAC Name:
- 2-phenoxyethan-1-ol
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2-phenoxyethanol (technical grade)
- Physical state: colourless liquid
- Analytical purity: ca. 80% 2-phenoxyethanol
- Composition of test material, percentage of components: 2-phenoxyethanol, (ca. 80% 2-phenoxyethanol, ca. 18% monophenyldiglycol, ca. 0.5% monophenyltriglycol)
- Lot/batch No.: substance number: 82/135
- Expiration date of the lot/batch: May 1983
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomae GmbH, Germany
- Age at study initiation: ca. 12 weeks
- Weight at study initiation (mean): 188 g (males), 180 g (females)
- Fasting period before study: 16 h, but water was available
- Diet (e.g. ad libitum): conventional laboratory
- Water (e.g. ad libitum): drinking water
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 6.81, 14.70, 31.60, 50.00 %
- Amount of vehicle (if gavage): 10 mL/kg b.w.
- Other: 0.5 % aqueous carboxymethyl cellulose solution - Doses:
- 681, 1470, 3160, and 5000 mg/kg b.w.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs (once daily)
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 840 mg/kg bw
- 95% CL:
- 1 010 - 2 960
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 4 070 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 740 mg/kg bw
- 95% CL:
- 1 910 - 4 050
- Mortality:
- All animals dosed with 681 mg/kg b.w. survived the 14 d observation period. All males survived a treatment of 1470 mg/kg b.w., whereas 2 out of 5 female rats died. At a dose level of 3160 mg/kg b.w., 2 males and 4 females died, respectively. At the highest dose level 3 male and all female animals died. In all treatment groups, the latest time point where death occurred was observation day 1. Generally females were more susceptible to 2-phenoxyethanol compared to males.
Increasing dose resulted in increased mortality. - Clinical signs:
- other: Dyspnoea; apathy; abnormal position; staggering; atony; deficiency in pain and cornea reflex; coma-like state; spastic gait; rough fur; exsiccosis; exophthalmoses; general poor condition
- Gross pathology:
- Animals that died during the study course revealed following signs at necropsy:
Congestion; lungs which were slightly inflated; sporadically reddened glandular stomach
Any other information on results incl. tables
Dose [mg/kg b.w.] |
Number of dead/ |
Time of death
|
Observations
|
|
Males |
||||
681 |
0 |
-- |
dyspnoea; apathy; abnormal position; staggering; atony; paresis |
|
1470 |
0 |
-- |
dyspnoea; apathy; abnormal position; staggering; atony; deficiency in pain and cornea reflex; coma-like state; |
|
3160 |
2 |
1 d |
dyspnoea; apathy; abnormal position; staggering; atony; deficiency in pain and cornea reflex; coma-like state; |
|
5000 |
3 |
1 d |
dyspnoea; apathy; abnormal position; staggering; atony; deficiency in pain and cornea reflex; coma-like state; spastic gait; rough fur; exsiccosis; exophthalmoses; general poor condition |
|
LD50value |
4070 mg/kg b.w. |
|
||
Females |
||||
681 |
0 |
-- |
dyspnoea; apathy; abnormal position; staggering; atony; paresis |
|
1470 |
2 |
1 d |
dyspnoea; apathy; abnormal position; staggering; atony; deficiency in pain and cornea reflex; coma-like state; |
|
3160 |
4 |
1 d |
dyspnoea; apathy; abnormal position; staggering; atony; deficiency in pain and cornea reflex; coma-like state; |
|
5000 |
5 |
1 h (3 animals); 1 d (2 animals) |
dyspnoea; apathy; abnormal position; staggering; atony; deficiency in pain and cornea reflex; coma-like state; exsiccosis; exophthalmoses; general poor condition |
|
LD50value |
1840 mg/kg b.w. |
|
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- CLP: acute toxicity Cat. 4
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