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EC number: 202-615-1 | CAS number: 97-88-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Butyl methacrylate
- EC Number:
- 202-615-1
- EC Name:
- Butyl methacrylate
- Cas Number:
- 97-88-1
- Molecular formula:
- C8H14O2
- IUPAC Name:
- butyl methacrylate
- Details on test material:
- - Name of test material (as cited in study report): n-butylmethacrylat
- Physical state: liquid
- Analytical purity: 99.8%, stabilized with 100 ppm hydroquinonemonomethylether
- Impurities (identity and concentrations): no data
- Purity test date: no data
- Lot/batch No.: no data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Lippische Versuchstierzucht, Hagemall GmbH & Co. KG
- Age at study initiation: 8-10 W
- Weight at study initiation: no data
- Housing: individually
- Diet (e.g. ad libitum): mümmel z, ssniff/Soest
- Water (e.g. ad libitum): tap water
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 +/- 2
- Humidity (%): 40 - 50
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- Amount applied: 0.1 ml
- Duration of treatment / exposure:
- The test eyes were not washed out following the instillation
- Observation period (in vivo):
- 1, 24, 48 and 72 hours as well as 8 days
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
SCORING SYSTEM: Draize scale
TOOL USED TO ASSESS SCORE: hand-slit lamp and fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: #1, #2, #3
- Time point:
- other: mean 24+48+72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Observation time: 8 days
- Irritation parameter:
- iris score
- Basis:
- animal: #1, #2, #3
- Time point:
- other: mean 24+48+72 h
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- other: Observation time: 8 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: #1, #3
- Time point:
- other: mean 24+48+72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: Observation time: 8 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: mean 24+48+72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Observation time: 8 days
- Irritation parameter:
- chemosis score
- Basis:
- animal: #1, #2
- Time point:
- other: mean 24+48+72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Observation time: 8 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- other: mean 24+48+72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: Observation time: 8 days
- Irritant / corrosive response data:
- One hour after dosing, two animals exhibited slight conjunctival redness, chemosis and discharge, which persisted for 24 hours in one animal. The second animal also exhibited conjunctival redness at 24 hours after dosing. At 48 hours following dosing all signs of irritation had resolved. The remaining animal showed no signs of irritation at any time during the test.
Any other information on results incl. tables
Classification of eye irritation studies according GHS-criteria
Substance:n-Butyl methacrylate CAS: 97-88-1
Source: UNTER 88-022
Animal No. |
Corneal opacity/Hornhauttrübung[Scores]
|
Mean Draize score in 2 of 3 animals |
Reversibility [scores] |
Hazard category |
|||
after 24 h |
after 48 h |
after 72 h |
in 7 days |
in 21 days |
|
||
1 |
0 |
0 |
0 |
0 |
0 |
|
|
2 |
0 |
0 |
0 |
0 |
0 |
|
|
3 |
0 |
0 |
0 |
0 |
0 |
|
|
|
|
|
|
0 |
|
|
none |
|
|
|
|
|
|
|
|
Animal No. |
Iritis/Regenbogenhautentzündung[Scores]
|
Mean Draize score in 2 of 3 animals |
Reversibility [scores] |
Hazard category |
|||
after 24 h |
after 48 h |
after 72 h |
in 7 days |
in 21 days |
|
||
1 |
0 |
0 |
0 |
0 |
0 |
|
|
2 |
0 |
0 |
0 |
0 |
0 |
|
|
3 |
0 |
0 |
0 |
0 |
0 |
|
|
|
|
|
|
0 |
|
|
none |
|
|
|
|
|
|
|
|
Animal No. |
Conjunctiva redness (erythem) /Bindehautrötung[Scores]
|
Mean Draize score in 2 of 3 animals |
Reversibility [scores] |
Hazard category |
|||
after 24 h |
after 48 h |
after 72 h |
in 7 days |
in 21 days |
|
||
1 |
1 |
0 |
0 |
0.33 |
0 |
|
|
2 |
0 |
0 |
0 |
0 |
0 |
|
|
3 |
1 |
0 |
0 |
0.33 |
0 |
|
|
|
|
|
|
|
|
|
none |
Animal No. |
Conjunctiva chemosis /Bindehautödem[Scores]
|
Mean Draize score in 2 of 3 animals |
Reversibility [scores] |
Hazard category |
|||
after 24 h |
after 48 h |
after 72 h |
in 7 days |
in 21 days |
|
||
1 |
0 |
0 |
0 |
0 |
0 |
|
|
2 |
0 |
0 |
0 |
0 |
0 |
|
|
3 |
1 |
0 |
0 |
0.33 |
0 |
|
|
|
|
|
|
|
|
|
none |
Classification: Hazard Category |
none |
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information not classified Criteria used for interpretation of results: other: REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 16 December 2008
- Conclusions:
- Classification: not irritating
- Executive summary:
In an OECD 405 guideline study, n-butyl methacrylate (0.1 ml) was placed in the conjunctival sac of the right eye of three New Zealand White rabbits. The lids were then gently held together for one second. The test eyes were not washed out following the instillation. The left eye remained untreated for control. The eyes were examined at 1, 24, 48 and 72 hours as well as 8 days from beginning of test. Eye irritation was scored for signs of corneal damage (density, area), iris reaction and lesions of the conjunctivae (erythema, chemosis, discharge). Additionally, the cornea was examined with the aid of fluorescein after recording the observations at 24 hours. One hour after dosing, two animals exhibited slight conjunctival redness, chemosis and discharge, which persisted for 24 hours in one animal. The second animal also exhibited conjunctival redness at 24 hours after dosing. At 48 hours following dosing all signs of irritation had resolved. The remaining animal showed no signs of irritation at any time during the test. n-Butyl methacrylate is considered as slightly irritating to eyes.
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