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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 205-426-2 | CAS number: 140-66-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- other: expert judgement
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: UK Environmental Risk Evaluation Report (ERAR) 2005 on 4-tert-octylphenol: assumed to be reliable information source
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- UK Environmental Risk Evaluation Report (ERAR) 2005: literature review
- GLP compliance:
- not specified
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Hydrolysis of 4-tert-octylphenol is not expected.
- Executive summary:
The UK Environmental Risk Evaluation Report (ERAR) 2005 on 4-tert-octylphenol states that hydrolysis would not be expected in view of the chemical structure. In addition, based upon the stability of 4-tert-octylphenol during storage and lack of degradation in controls in biodegradation studies cited in the UK ERAR 2005, it is likely that abiotic degradation is a negligible removal process. Therefore, hydrolysis is believed to be a negligible removal process for 4-tert-octylphenol in the aquatic environment.
Reference
Description of key information
In accordance with REACH Annex XI, there is sufficient weight of evidence from several independent sources of information leading to the conclusion that hydrolysis is not an important abiotic degradation pathway for 4-tert-octylphenol. Therefore, hydrolysis testing for 4-tert-octylphenol is not scientifically necessary.
Key value for chemical safety assessment
Additional information
As stated in the ECHA Guidance Document R.7B, p. 233, hydrolysis is not an important fate process for petroleum substances since hydrocarbons do not undergo reaction with water. 4-tert-octylphenol is also a substance among the hydrocarbons consisting of an alkylchain with eight C atoms attached to a phenol ring. This means that also for 4-tert-octylphenol hydrolysis is not a dominant route of abiotic degradation.
This assumption is in accordance with the presumption of Melcer et al., 2007 (p. 11). This study did not expect hydrolysis to be important for alkylphenol ethoxylates and alkylphenols because of their chemical structures and the lack of functional groups susceptible to hydrolytic attack.
This assumption is further supported by the UK Environmental Risk Assessment (ERA) Report 2005 on 4-tert-octylphenol which states that hydrolysis would not be expected in view of the chemical structure. In addition, based upon the stability of 4-tert-octylphenol during storage and lack of degradation in controls in biodegradation studies cited in the UK ERA Report 2005, it is likely that abiotic degradation is a negligible removal process. Therefore, hydrolysis is believed to be a negligible removal process for 4-tert-octylphenol in the aquatic environment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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