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Diss Factsheets
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EC number: 205-011-6 | CAS number: 131-11-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study is not assignable. Only secondary literature and only short table available. However, reliable key studies with restrictions (non-GLP studies) are available for the first, the oral route via (gavage) and second, the dermal route. These routes are likely to be of more human relevance than the inhalative route due to the low vapour pressure of the substance.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Inhalation toxicity tests-Environmental assessment & toxicology Monsanto company
- Author:
- Levinskas GJ.
- Year:
- 1 973
- Bibliographic source:
- Techn. Pap. Reg. Tech. Conf. p. 95-100. Soc . Plastics Engineers Inc.
- Reference Type:
- secondary source
- Title:
- Toxicity Profile, Dimethylphthalate, November 1987
- Author:
- BIBRA
- Year:
- 1 987
- Bibliographic source:
- BIBRA
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- ECB-IUCLID
- Year:
- 2 000
- Bibliographic source:
- European Chemicals Bureau, 11-FEB-2000
Materials and methods
- Principles of method if other than guideline:
- Method: other: Industrial acute inhalation toxicity test, groups of animals were exposed for 4h to graded air concentrations of the test substance and observed 14 days thereafter
- GLP compliance:
- no
- Test type:
- other: inhalation toxicity test, no further details
Test material
- Reference substance name:
- Dimethyl phthalate
- EC Number:
- 205-011-6
- EC Name:
- Dimethyl phthalate
- Cas Number:
- 131-11-3
- Molecular formula:
- C10H10O4
- IUPAC Name:
- 1,2-dimethyl benzene-1,2-dicarboxylate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Method of conditioning air: air was bubbled through the material and led directly into a chamber containing the animals, this results in an air stream near saturation; saturated vapor exposure
- Duration of exposure:
- 6 h
- Concentrations:
- Only stated: saturated atmosphere (limited reporting); the calculated saturated vapour pressure is 10.4mg/L (based on vapour pressure 0.0013hPa at 20°C and the molecular weight 194.2g/mol) - an aerosol of the test substance might have been generated.
- No. of animals per sex per dose:
- no details reported
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 10.4 mg/L air (nominal)
- Exp. duration:
- 6 h
- Remarks on result:
- other: no concentration/dose reported, only saturated vapor; calculation of concentration based on the molecular weight of the test substance (194.2g/mol); an aerosol might have been generated
- Mortality:
- There were no deaths when an unspecified number of rats were exposed to the saturated vapour for 6 h within observation period of 14 days.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 for acute inhalation toxicity is greater than 10.4 mg/L/6h at saturated vapor.
- Executive summary:
The study is not assignable, only published in a short table (secondary literature) and reporting is very limited (non-GLP study). Acute inhalation toxicity (6h saturated vapor) was tested in rats, no mortalities were observed within 14 days. However, an aerosol might have been generated.
The LD50 for acute inhalation toxicity is greater than 10.4 mg/L/6h at saturated vapor.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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