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Diss Factsheets
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EC number: 206-114-9 | CAS number: 302-01-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: description sufferes from deficiencies because no individual animal data were given.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The acute toxicity of the vapours of some methylated hydrazine derivatives
- Author:
- Jacobson KH, Clem JH, Wheelwright HJ, Rinehart WE, Mayes N
- Year:
- 1 955
- Bibliographic source:
- AMA Arch. Ind. Health 12, 609-616
- Reference Type:
- publication
- Title:
- The Toxicology of an Aniline-Furfuryl Alcohol-Hydrazine Vapor Mixture.
- Author:
- Jacobson KH, Rinehart WE, Wheelwright jr HJ, Ross MA, Papin JL, Daly R, Greene EA, Groff WA
- Year:
- 1 958
- Bibliographic source:
- J. Am. Ind. Hyg. Assoc. 19, 91-100.
Materials and methods
- Principles of method if other than guideline:
- Method: 5 concentrations tested; 10 animals per group; 14 days post exposure observation period.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Hydrazine
- EC Number:
- 206-114-9
- EC Name:
- Hydrazine
- Cas Number:
- 302-01-2
- Molecular formula:
- H4N2
- IUPAC Name:
- hydrazine
- Details on test material:
- IUCLID4 Test substance: other TS: hydrazine, no data on purity; M.P. 1.4 °C
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- no further data
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: other
- Details on inhalation exposure:
- Chamber concentration were established by passing dry nitrogen through a bubbbler containing the liquid agent.The vapour was mixed with air in a glass premixing bowl, and this mixture was then drawn into a constant flow gassing chamber. A 0.4m³ chamber operated at an air flow of 0.10 to 0.115 m³ per minute. Samples of chamber air were drawn into Vigreaux-type bubblers containing water acidified with a drop of concentrated hydrochloric acid. Analyses of hydrazine was performed by potentiometric bromate titration.
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 400 - 800 ppm
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- 5 concentrations tested;
10 animals per group;
14 days post exposure observation period;
one group of rats at each concentration was killed periodically
after exposure for a study of pathological changes. The other
group was observed for development of toxic signs during
exposure and for 14 days thereafter. - Statistics:
- method of Bliss as described by Finney
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 570 ppm
- 95% CL:
- 504 - 649
- Exp. duration:
- 4 h
- Remarks on result:
- other: corresponding to 759 mg/m³
- Mortality:
- Individual data are not given, only a graphic: range between 20 and 90 %.
- Clinical signs:
- other: Restlessness, dyspnea, clonic convulsions with exophthalmos.
- Body weight:
- no data
- Gross pathology:
- no data
- Other findings:
- no data
Any other information on results incl. tables
LC50: 0.759 mg/l; 95% confidence limits 504-649 ppm.
Clinical signs: restlessness, dyspnea, convulsions.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 based on GHS criteria
- Executive summary:
10 male rats/group were exposed to 400 -800 ppm for 4 hours and displayed restlessness, dyspnea and convulsions, and resulted in a LC 50 (male rat) of 570 ppm (759 mg/m³, Jacobson 1955).
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