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EC number: 204-469-4 | CAS number: 121-44-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17. Jun 1958 - 24 Jun 1958
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 960
- Report date:
- 1960
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- observation period was 7 days
- Principles of method if other than guideline:
- BASF-Test: The study was conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401.
Animals were treated by single gavage application with an aqueous solution of the test substance. The animals were observed for mortality and for clinical symptoms of toxicity. At the end of the observation period of 7 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy. - GLP compliance:
- no
- Test type:
- other: acute oral toxicity method (OECD 401)
- Limit test:
- no
Test material
- Reference substance name:
- Triethylamine
- EC Number:
- 204-469-4
- EC Name:
- Triethylamine
- Cas Number:
- 121-44-8
- Molecular formula:
- C6H15N
- IUPAC Name:
- triethylamine
- Details on test material:
- - Name of test material (as cited in study report): Triaethylamin
- Impurities (identity and concentrations): up to 1 % diaethylamin
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 119 - 200 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 1, 10 and 20 % - Doses:
- 20, 79, 316, 501, 794, 1260, 5010 cm³/kg bw (15, 58, 230, 366, 580, 920 and 3660 mg/kg bw - conversion in mg/kg is based on the denisty: 0.73 g/cm³).
Two animals also received the TS undiluted at 920 and 3660 mg/kg. - No. of animals per sex per dose:
- 15 and 58 mg/kg bw: 1 (no gender stated)
230, 366 and 580 mg/kg bw: 5 (no gender stated)
920 and 3660 mg/kg bw: 5 animals were treated with diluted and 1 animal with undiluted test substance. - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 730 mg/kg bw
- Remarks on result:
- other: no further information available
- Mortality:
- No animals died in the five lowest dose groups (0/1, 0/1, 0/5, 0/5 and 0/5). In the 920 mg/kg dose group 4/6 animals died within the first 24 h. In the 3660 mg/kg dose 1/1 animal died within the first h. The animals that received the undiluted test substance died within approx. 1 h of administration.
- Clinical signs:
- other: 580 mg/kg bw: 24 h post application unkempt fur was observed. 920 mg/kg bw: strong trembling and convulsions occured and by approx. 2 h 3/6 animals had died; the next day unkempt fur and blood crusted nose and snouts were observed. The animal that receiv
- Gross pathology:
- The animals that received the undiluted test substance had stomachs filled with dark red contents.
Any other information on results incl. tables
Mortality:
Dose (mg/kg bw) | conc (%) | 1 h | 24 h | 48 h | 7 days |
3660 | 100 | 1/1 | 1/1 | 1/1 | 1/1 |
3660 | 20 | 1/1 | 1/1 | 1/1 | 1/1 |
929 | 10 | 0/5 | 3/5 | 3/5 | 3/5 |
929 | 100 | 1/1 | 1/1 | 1/1 | 1/1 |
580 | 10 | 0/5 | 0/5 | 0/5 | 0/5 |
366 | 10 | 0/5 | 0/5 | 0/5 | 0/5 |
230 | 10 | 0/5 | 0/5 | 0/5 | 0/5 |
58 | 1 | 0/1 | 0/1 | 0/1 | 0/1 |
15 | 1 | 0/1 | 0/1 | 0/1 | 0/1 |
Applicant's summary and conclusion
- Interpretation of results:
- moderately toxic
- Remarks:
- Migrated information medium to moderate Criteria used for interpretation of results: expert judgment
- Conclusions:
- The test substance caused systemic toxicity (including mortality) and local irritation in a dose dependent manner.
- Executive summary:
The study was conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401. Triethylamine was administered to rats by gavage as solution in olive oil. Concentrations in vehicle were 1% (15 and 58 mg/kg/bw), 10% (230, 366, 580 and 929 mg/kg/bw), 20% (3660 mg/kg/bw) and undiluted (929 and 3660 mg/kg/bw). No mortalities were observed in the five lowest dose groups. In the 920 mg/kg dose group 4/6 animals died within the first 24 h. In the 3660 mg/kg dose 1/1 animal died within the first hour. The animals that received the undiluted test substance died within approx. 1 h of administration. The animals that received high doses of the test material showed convulsions and strong trenor. The severity of these effects was enchanced in a dose-dependent manner.
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