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EC number: 402-130-7 | CAS number: 106246-33-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 305 C (Bioaccumulation: Test for the Degree of Bioconcentration in Fish)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Chemical Substances Control Law (Japanese Law No.117, 1973).
- Deviations:
- no
- GLP compliance:
- yes
- Radiolabelling:
- no
- Details on sampling:
- Concentrations of the test substance in water and in whole fish body were measured periodically.
- Vehicle:
- yes
- Remarks:
- 2-Methoxyethanol solution of HC0-30 (disperse medium)
- Details on preparation of test solutions, spiked fish food or sediment:
- PREPARATION OF TEST SOLUTIONS
1) Exposure Level:
Four hundred milligrams of the test substance were dissolved and diluted to 20 mL with the 2-Methoxyethanol solution of HC0-30 (disperse medium) (test substance conc.: 20 mg/mL, HC0-30 conc.: 400 mg/mL). Two point five, five, and ten milliliters of this solution were dropped with stirring in dechlorinated water (Yokohama municipal tap water was treated with activated charcoal and then aerated) and diluted to 2 L to make test concentrations of
25, 50, 100/Lg/mL. The concentration of HC0-30 ranged from 500 to 2000 µg/mL.
2) Control Level:
The 2-Methoxyethanol solution of HC0-30 (HC0-30 conc.: 400 mg/mL), 10 mL, was diluted to 2 L with dechlorinated water. The final concentration of HC0-30 was 2000 µg/mL. - Test organisms (species):
- Oryzias latipes
- Details on test organisms:
- 1) Test fish
- Species: Orange killifish (Oryzias latipes)
- Source: Niikura Fishing (1217 Simotani, Isehara, Kanagawa)
- Date of purchase: July 22, 1996
- Lot No.: 96-H-0722
- Body length: approx. 2 cm
- Body weight: approx. 0.2 g
2) Acclimation:
- Water temperature: 25±2°C
- Period: over 1 week
- Feeding: Feed (Tetramin, Tetra Werke, Germany) of approx. 2% of the body weight was given to fish once a day except holidays and for 48 hours before testing - Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 10 wk
- Hardness:
- not indicated
- Test temperature:
- 23.8 - 24.6°C (measured value)
- pH:
- not measured
- Dissolved oxygen:
- 6.6- 7.1 ppm (measured value)
- TOC:
- no data
- Salinity:
- freshwater used
- Details on test conditions:
- - Test vessel:
85 l glass aquarium with 80 l water
- Type: open
- Aeration: continuous
- Type of flow-through (e.g. peristaltic or proportional diluter): Continuous flow-through diluter system (800 L/day); the turnover rate for each aquaria was 10 times per day.
- Renewal rate of test water: none
- No. of organisms per vessel: 18 fish each for low and high exposure level / 12 fish for control
- Flow rate of dilution water 800 L/day
- Flow rate of feed solution 20 mL/day - Nominal and measured concentrations:
- Nominal concentrations of the test substance in water :
- High exposure level 0.2 µg/mL (HC0-30 conc. 4 µg/mL)
- Low exposure level 0.02 µg/mL (HC0-30 conc. 0.4 µg/mL)
- Control 0 µg/mL (HC0-30 conc. 4 µg/mL) - Reference substance (positive control):
- no
- Key result
- Conc. / dose:
- ca. 0.19 µg/L
- Temp.:
- ca. 24 °C
- Type:
- BCF
- Value:
- 1 668 - 6 370 dimensionless
- Basis:
- not specified
- Time of plateau:
- 6 wk
- Calculation basis:
- kinetic
- Key result
- Conc. / dose:
- ca. 0.019 µg/L
- Temp.:
- ca. 24 °C
- Type:
- BCF
- Value:
- 2 989 - 14 908 dimensionless
- Basis:
- not specified
- Time of plateau:
- 10 wk
- Calculation basis:
- kinetic
- Remarks on result:
- other: equilibrium not reached after 10 weeks
- Metabolites:
- not measured
- Results with reference substance (positive control):
- no positive control tested
- Details on results:
- At high exposure level, the bioeoncentration factor of the test substance was determined to be 1668 - 6370 and reached to equilibrium after 6 weeks. Atlow exposure level, it was determind to be 2989 - 14908 and was not reached to
equilibrium in 10 weeks. As bioconcentration factor of the test substance at low exposure level resulted about 15000 and not reached to equilibrium, the study was stopped. - Validity criteria fulfilled:
- no
- Conclusions:
- At high exposure level, the bioeoncentration factor of the test substance was determined to be 1668 - 6370 and reached to equilibrium after 6 weeks. Atlow exposure level, it was determind to be 2989 - 14908 and was not reached to
equilibrium in 10 weeks. As bioconcentration factor of the test substance at low exposure level resulted about 15000 and not reached to equilibrium, the study was stopped. - Executive summary:
This study was conducted to evaluate the bioconcentration potential of the test substance for notification under the Chemical Substances Control Law, Japan, following the Japanese testing methods and OECD 305C: Orange killifish was the species used. At high exposure level (0.19 µg/mL), the bioconcentration factor of the test substance was determined to be 1668 - 6370 and reached to equilibrium after 6 weeks. At low exposure level (0.019 µg/mL), BCF was determined to be 2989 - 14908 and was not reached to equilibrium in 10 weeks. Therefore, the study was stopped. A complete test at low exposure level was technically not possible.
Reference
Description of key information
Bioaccumulation in fish (stopped):
This study was conducted to evaluate the bioconcentration potential of the test substance for notification under the Chemical Substances Control Law, Japan, following the Japanese testing methods and OECD 305C: Orange killifish was the species used. At high exposure level (0.19 µg/mL), the bioconcentration factor of the test substance was determined to be 1668 - 6370 and reached to equilibrium after 6 weeks. At low exposure level (0.019 µg/mL), BCF was determined to be 2989 - 14908 and was not reached to equilibrium in 10 weeks. Therefore, the study was stopped. A complete test at low exposure levels was technically not possible.
However, based on the intended uses of the test item, direct and indirect exposure of the aquatic compartment is very unlikely.
Key value for chemical safety assessment
Additional information
Source: GLP-report & expert assessment
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