Registration Dossier
Registration Dossier
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EC number: 617-969-6 | CAS number: 87135-01-1
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In a skin sensitisation study in the guinea pig, conducted according to OECD 406 (Buehler method) and in compliance with GLP, 1,6-bis(trimethoxysilyl)hexane was not sensitising (Dow Corning Corporation, 2009c). There were no positive skin reactions in any animals following treatment with an induction concentration of 50% in PEG 300 and challenge concentrations of 1% and 10%.
Migrated from Short description of key information:
In a skin sensitisation study in the guinea pig, conducted according to OECD 406 (Buehler method) and in compliance with GLP, 1,6-bis(trimethoxysilyl)hexane was not sensitising (Dow Corning Corporation, 2009c).
Justification for selection of skin sensitisation endpoint:
The selected study is the only available skin sensitisation test for this substance. It was conducted in accordance with an appropriate OECD test guideline and in compliance with GLP.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the available in vivo study, the substance is not classified for skin sensitisation according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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