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EC number: 231-555-9 | CAS number: 7632-00-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
Key value for chemical safety assessment
Justification for classification or non-classification
Additional information
In a two-year chronic toxicity/carcinogenicity study [NTP, 2001] male and female F344/N rats were exposed to 0, 750, 1500 or 3000 ppm sodium nitrite (equivalent to average daily doses of approximately 0, 35, 70 or 130 mg/kg bw/day in males and 0, 40, 80 or 150 mg/kg bw/day in females) in drinking water. There were no clinical findings related to exposure. Methaemoglobin levels were measured at two weeks and three months. At both 2 weeks and three months, methaemoglobin levels were high at night when the rats were actively feeding and drinking and low during the day when the rats were less active. Methaemoglobin levels tended to increase with increasing dosage.
In a second two-year study [NTP, 2001] male and female B6C3F1 mice were exposed to 0, 750, 1500 or 3000 ppm sodium nitrite (equivalent to average daily doses of approximately 0, 60, 120 or 220 mg/kg bw/day for males and 0, 45, 90 or 165 mg/kg bw/day for females) in drinking water. There were no clinical findings related to exposure. At 12 months, no significant increase in methaemoglobin level was observed in either sex at any dose.
Based on the two-year studies, the NOAELs for rats were 130 mg/kg bw/day in males and 150 mg/kg bw/day in females. For mice the NOAELs were 220 mg/kg bw/day in males and 165 mg/kg bw/day in females.
Maekawa et al. (1982) reported about the carcinogenicity of sodium nitrite and sodium nitrate. Male and female rats were offered continuously concentrations of 0.25 or 0.125% sodium nitrate/rat/day via the drinking water over a study period of 2 years. The authors concluded that sodium nitrite did not have carcinogenic activity in rats.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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