Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-767-1 | CAS number: 7722-88-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to birds
Administrative data
- Endpoint:
- long-term toxicity to birds: reproduction test
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Meets generally accepted scientific standards with acceptable restrictions. Study is not considered to be of relevance for REACH registration.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity and teratogenicity of food additive chemicals in the developing chicken embryo.
- Author:
- Verrett, MJ, Scott WF, Reynaldo EF, Alterman EK & Thomas CA.
- Year:
- 1 980
- Bibliographic source:
- Toxicology and Applied Pharmacology 56: 265 - 273.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: No data
- Deviations:
- not specified
- Principles of method if other than guideline:
- The toxicity of 80 chemicals used as food additives were investigated by their administration to developing chicken embryos. Four test conditions were used: Injection via the air cell and via the yolk; and at two times, preincubation (0 h) and 96 h. For each condition, at least 100 embryos per dose level were treated at a minimum of five dose levels. Appropriate groups of vehicle controls and untreated controls were included in all experiments. LD50 values were determined for each test condition. All embryos and hatched chicks were examined grossly for any abnormalities in development, both functional and structural. All abnormalities were tabulated and compared with values for the vehicle controls to determine teratogenicity. Levels tested ranged from 0.5 to 75 mg/egg; the maximum volume injected was 100 μL.
- GLP compliance:
- no
- Remarks:
- Study pre-dates GLP.
Test material
- Reference substance name:
- Tetrasodium pyrophosphate
- EC Number:
- 231-767-1
- EC Name:
- Tetrasodium pyrophosphate
- Cas Number:
- 7722-88-5
- Molecular formula:
- H4O7P2.4Na
- IUPAC Name:
- tetrasodium (phosphonatooxy)phosphonate
- Details on test material:
- - Name of test material: Monocalcium phosphate, tricalcium phosphate, monopotassium phosphate, monosodium phosphate, sodium hexametaphosphate, tetrasodium pyrophosphate.
Constituent 1
- Dose method:
- other: Injection into the egg yolk or air sac.
- Analytical monitoring:
- not specified
- Vehicle:
- yes
Test organisms
- Test organisms (species):
- other: Chicken
Study design
- Limit test:
- no
- Remarks:
- Single injection.
- No. of animals per sex per dose and/or stage:
- Not applicable, administration was to eggs. Approx. 100 eggs per test condition were used.
- Control animals:
- yes
Results and discussion
- Repellency factors (if applicable):
- No data
Any other information on results incl. tables
Monocalcium phosphate, tricalcium phosphate and monopotassium phosphate showed no teratogenic response. Only a few severe terata were seen after preincubation administration of monosodium phosphate in water by either yolk or air cell route. With administration at 96 h, however, numerous severe anomalies occurred at all dose levels for both routes. The anomalies included buphthalmia and cleft palate, celosomia, exencephaly, microcephaly, brachyganthia, hyperplasia of the heart, ablepharia, torticollis, microphthalmia, anophthalmia, coloboma, ectromalia and phocomelia.
Sodium hexametaphosphate showed essentially the same results in water as those indicated for monosodium phosphate. In addition to the severe structural anomalies, a large number of newly hatched birds were ataxic, with lack of control of the head and neck muscles.
Significant toxicity was produced by tetrasodium pyrophosphate in water under all conditions between 0.125 and 5 mg/egg. Serious terata were seen under three conditions of th etes; yolk treatment at 0 h resulted in only 1 bird with a serious anomaly (ectopia cardis). The other treatments resulted in many birds with severe and usually multiple terata. After air cell administration at 0 h, such abnormal birds occurred at all test levels at an incidence greated than solvent background, although the difference was not significant at the p = 0.05 level. Treatment at 96 h for both routes of administration resulted in significant increases (p≤ 0.05) at most of the test levels. The abnormalities observed were those described for the other phosphate compounds.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Monocalcium phosphate, tricalcium phosphate and monopotassium phosphate showed no teratogenic response. Monosodium phosphate, sodium hexametaphosphate and tetrasodium pyrophosphate produced teratogenic effects in the developing chicken embryo.
Study is not considered to be of relevance for REACH registration and therefore results cannot be used in a meaningful way and should be disregarded.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.