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EC number: 203-794-9 | CAS number: 110-71-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 June - 15 August 1984
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well performed and reported guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 412 (Subacute Inhalation Toxicity: 28-Day Study)
- Version / remarks:
- 1981
- Deviations:
- no
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- 1,2-dimethoxyethane
- EC Number:
- 203-794-9
- EC Name:
- 1,2-dimethoxyethane
- Cas Number:
- 110-71-4
- Molecular formula:
- C4H10O2
- IUPAC Name:
- 1,2-dimethoxyethane
- Details on test material:
- Purity: 99.8%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Hoe: WISKf (SPF 71)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hoechst AG, Pharma Forschung Toxikologie
- Age at study initiation: males 45 days; females 40 days
- Weight at study initiation: males 158-189 g, females 158-191 g
- Housing: in groups of 3 or 4 animals in Makrolon type-3 cages with wire mesh tops and standard softwood bedding
- Diet (e.g. ad libitum): Altromin R 1324 pellets ad libitum
- Water (e.g. ad libitum): Community tap water ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2 °C
- Humidity (%): 50 +/- 20 %
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 27.06.1984 To: 15.08.1984
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- clean air
- Remarks on MMAD:
- MMAD / GSD: n.a.
- Details on inhalation exposure:
- Exposure period: 14 days
Recovery period: 36 days
Control group: Yes, concurrent to treatment (air)
Method: OECD 412 (OECD 1981)
10 males and 10 females were used per group (whole body exposure).
Ethylene glycol dimethyl ether was applied to a vaporizer and continuously evaporated at 80°C. The resulting test substance/air mixture was carried to the inhalation chambers (2.25 m3) using an air stream of 800 L/h. The Ethylene glycol dimethyl ether concentration was determined by a Miran 80 photometer every 30 min. CO, CO2 (Uras 2 T Infrared-Gasanalysator) and O2 (Magnos 3 magnetic Oxygen-Analysator) concentration as well as humidity (Transmitter HMT 12) and temperature (CMR-Meßumformer TEU 320) were determined continuously. - Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- Please refer to "Details on inhalation exposure"
- Duration of treatment / exposure:
- 6 hours/d
- Frequency of treatment:
- 5 days/week
Doses / concentrationsopen allclose all
- Dose / conc.:
- 10 ppm (analytical)
- Remarks:
- Doses / Concentrations:
10 ppm (0.037 mg/L)
Basis:
analytical conc.
- Dose / conc.:
- 50 ppm (analytical)
- Remarks:
- Doses / Concentrations:
50 ppm (0.187 mg/L)
Basis:
analytical conc.
- Dose / conc.:
- 250 ppm (analytical)
- Remarks:
- Doses / Concentrations:
250 ppm (0.935 mg/L)
Basis:
analytical conc.
- No. of animals per sex per dose:
- 10
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Animals were observed for mortality and clinical symptoms once before each exposure, several times during exposure, once after each exposure and daily during the recovery period. Body weights were recorded before treatment and weekly during the study, food and water consumption were determined weekly. Haematological examination (haemoglobin concentration, reticulocyte count, haematocrit, erythrocyte count, leucocyte count, thrombocyte count, differential blood count, thromboplastin time, Heinz body count, activated partial thromboplastin time and clotting time) and clinical biochemistry (sodium, potassium, bilirubin, creatinine, glucose, urea nitrogen, calcium, chloride, glutamic-pyruvic transaminase, glutamic-oxaloacetic transaminase, cholesterol, total serum protein, meth-haemoglobin, lactate dehydrogenase, phosphorus, lipids, electrophoresis) were performed in 10 animals per group (5 males and 5 females) one day after the last exposure and in the remaining animals 36 days after the last exposure. 10 rats of each dose group (5 males and 5 females) were sacrificed 1 day after the last treatment and the remaining animals 36 days after the last exposure and examined for gross macroscopical changes. Heart, spleen, lung, liver, kidney, brain, testis, ovary, seminal vesicle, adrenal, pituitary gland and thyroid gland were weighed and the relative organ weight was calculated. Full histopathology was carried out on numerous organs and tissues.
- Positive control:
- None
Examinations
- Observations and examinations performed and frequency:
- Clincal observations, body weight, food/water consumption, haematology, clinical biochemistry, ophthalmoscopy, organ weights, gross macroscopy, histology
For details please refer to "Details on study design" - Sacrifice and pathology:
- GROSS PATHOLOGY: Yes
HISTOPATHOLOGY: Yes - Other examinations:
- Please refer to "Details on study design"
- Statistics:
- no data
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- no effects observed
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- effects observed, treatment-related
- Description (incidence and severity):
- Water consumption of all females of the 50 ppm dose group was decreased from day 29 until termination of the study. Water consumption of all females of the 250 ppm dose group was decreased on study day 22 and 50.
- Ophthalmological findings:
- no effects observed
- Haematological findings:
- no effects observed
- Clinical biochemistry findings:
- no effects observed
- Endocrine findings:
- not examined
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- no effects observed
- Immunological findings:
- not examined
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- no effects observed
- Neuropathological findings:
- not examined
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Description (incidence and severity):
- No changes occurred at any dose level with the exception of the reduction of cell layers of seminiferous epithelium in male rats of the 250 ppm dose group. This effect was reversible. There were no such findings in the recovery group.
- Histopathological findings: neoplastic:
- no effects observed
- Other effects:
- no effects observed
Effect levels
- Dose descriptor:
- NOAEC
- Effect level:
- 0.187 mg/L air (analytical)
- Sex:
- male/female
- Basis for effect level:
- other: slight changes in the seminiferous epithelium, no changes in female rats at all doses
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Based on the observed slight changes in the seminiferous epithelium in male rats of the 250 ppm dose group, the NOEC is considered to be 50 ppm (0.187 mg/L). No effects were observed in female animals at any dosage.
- Executive summary:
A 14 day inhalation toxicity study was performed in rats. The animals were exposed to an Ethylene glycol dimethyl ether atmosphere of 0, 10 (0.037 mg/L), 50 (0.187 mg/L) and 250 ppm (0.935 mg/L).All animals survived and no clinical signs were noted at any dose level. No neurological or ophthalmological effects or changes in mucosa were noted. Body weight gain of all animals was not affected. There were no effects upon the mean daily food consumption observed at all dose levels. Water consumption of all females of the 50 ppm dose group was decreased from day 29 until termination of the study. Water consumption of all females of the 250 ppm dose group was decreased on study day 22 and 50. There were no haematological changes noted at any dose level.All determined clinical parameters were within the control range. Relative organ weights were within the control range.
No changes occurred at any dose level with the exception of the reduction of cell layers ofseminiferous epithelium in male rats of the 250 ppmdose group. This effect was reversible. There were no such findings in the recovery group.
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