Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-708-6 | CAS number: 688-84-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- other: Thesis
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 428 (Skin Absorption: In Vitro Method)
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-ethylhexyl methacrylate
- EC Number:
- 211-708-6
- EC Name:
- 2-ethylhexyl methacrylate
- Cas Number:
- 688-84-6
- Molecular formula:
- C12H22O2
- IUPAC Name:
- 2-ethylhexyl methacrylate
- Test material form:
- liquid
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 48 hours
- Doses:
- 100 µl/cm²
- Details on in vitro test system (if applicable):
- The absorption of 2-EHMA was evaluated through rat and human epidermis in an in vitro system.
Results and discussion
- Signs and symptoms of toxicity:
- not examined
- Dermal irritation:
- not examined
- Absorption in different matrices:
- Absorption of 2-EHMA through rat epidermis:
2-Ethylhexyl methacrylate readily absorbed through rat epidermis at a constant mean rate of 234 µg cm-2 hr-1. This rate of absorption was constant over the whole 30 hour exposure/sampling period. The total amount of chemical that was absorbed during the time of exposure was 7.8% of the donor reservoir.
2-EHMA through human epidermis:
2-ethylhexyl methacrylate appeared to have a lag time between 0 and 3 hrs, where the rate of absorption was calculated to be 7.72 µg cm-2 hr-1. The absorption rate increased to 22.7 µg cm-2 hr-1 and remained linear between 3 and 24 hrs. 0.551% of the applied dose was absorbed over the 24 hours of exposure.
Percutaneous absorptionopen allclose all
- Dose:
- 100 µl/cm²
- Parameter:
- percentage
- Absorption:
- 7.8 %
- Remarks on result:
- other: 30 hours
- Remarks:
- Rat epidermis
- Dose:
- 100 µl/cm²
- Parameter:
- percentage
- Absorption:
- 0.6 %
- Remarks on result:
- other: 24 hours
- Remarks:
- Human epidermis
- Conversion factor human vs. animal skin:
- Human epidermis appears to be 10 times less permeable to 2-EHMA than rat epidermis.
Applicant's summary and conclusion
- Conclusions:
- 2-EHMA readily absorbs through rat and human epidermis. Human epidermis appears to be 10 times less permeable to 2-EHMA than rat epidermis.
- Executive summary:
The absorption of 2-EHMA was evaluated through rat and human epidermis in an in vitro system. The technique measures the rate of absorption of 2 -EHMA across the epidermis. Glass diffusion cells are employed to measure the amount of 2 -EHMA that is received into a receptor chamber with respect to time, following the application of 100 µl/cm² of 2 -EHMA to the epidermal surface. The mean rate of absorption was 234 and 7.72 µg cm-2 hr-1 and the total amount of chemical that was absorbed during the time of exposure was 7.8 (over 30 hours) and 0.551% (over 24 hours), respectively. 2-EHMA appears readily absorbed through rat and human epidermis, but human epideremisc is 10 times less permeable to 2-EHMA than rat epidermis. However, measuring the rate of absorption through rat and human epidermis provides a quantitative estimate for inter-species differences; however, because only the epidermal layer is used, no measure of metabolism during skin absorption is possible.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)