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Diss Factsheets
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EC number: 248-145-0 | CAS number: 26966-75-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Full report, pre guideline and GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Single group exposure whole body to a concentration that was rising over the test period of 220 minutes.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3(or 4)-methylbenzene-1,2-diamine
- EC Number:
- 248-145-0
- EC Name:
- 3(or 4)-methylbenzene-1,2-diamine
- Cas Number:
- 26966-75-6
- Molecular formula:
- C7H10N2
- IUPAC Name:
- 3(or 4)-methylbenzene-1,2-diamine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Rats weighing between 200 and 300 g were used.
Maintainence was according to SOPs with ad lib food and water except during the exposure period.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- Animals were kept in individual wiremesh cages for exposure. The inhalation chamber was a 26.5 litre stainless steel jar mounted horizontally sealed with a transparent plexiglass sheet providing for air intake, exhaust and sampling.
Test material was held in a glass container in an oil bath kept at 130ºC, and vapours blown from the surface to the chamber at 180 l/hr. - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- GC method
- Duration of exposure:
- 4 h
- Concentrations:
- The concentrations analysed at 60, 120 and 180 minutes were 209, 500 and 1300ppm respectively.
This increase was ascribed to an increase in temperature of the melted material. - No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Details on study design:
- Single group, whole body exposure to a concentration that was rising over the test period of 220 minutes.
Control rats were held in the chamber without test material exposure.
Observation after exposure was for 14 days.
Two rats were sacrifices after 24 hours for examination.
Other animals were sacrificed after 14 days and autopsied. - Statistics:
- none
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LCLo
- Effect level:
- > 670 ppm
- Remarks on result:
- other: Effect level mean of chamber concentrations during exposure
- Mortality:
- None
- Clinical signs:
- other: Increased blinking and grooming during exposure.
- Body weight:
- no data
- Gross pathology:
- None seen
- Other findings:
- none
Any other information on results incl. tables
No adverse effects seen during exposure, during 14 days observation or on post mortem examination.
The LDlow is taken as a mean of the three chamber analysed concentrations. While this is a measured concentration the lack of adverse effects indicate the LClow is likely to be considerably higher than this value.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.