Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 429-460-4 | CAS number: 7078-98-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to GLP and in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not effect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Substituted Quinone Methide
- IUPAC Name:
- Substituted Quinone Methide
- Details on test material:
- Storage: The test article was stored at room temperature and humidity.
Description: Yellow crystalline solid.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Animals were received from Ace Animals, Boyertown, PA.
- Weight at study initiation: 2.2 - 2.5 kg
- Housing: 1 animap per cage in suspended wire cages. Bedding was placed beneath the cages and changed at least three times/week.
- Diet (e.g. ad libitum): Fresh Purina Rabbit Chow was provided daily.
- Water (e.g. ad libitum): Water was freely available at all times.
- Acclimation period: At least five days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): The animal room was temperature controlled.
- Photoperiod (hrs dark / hrs light): 12 hour light/dark cycle.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: 0.9% sodium chloride solution.
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): The test article was dosed by dry weight, 0.5 g/rabbit. - Duration of treatment / exposure:
- 4 hours.
- Observation period:
- 72 hours.
- Number of animals:
- 6 (3 males and 3 females).
- Details on study design:
- TEST SITE
- Area of exposure: The prepared site was approximately 10 x 10 cm and remained intact. The test article was placed under a 2.5 x 2.5 cm, moistened 4 ply, surgical gauze patch. The patch was moistened with approximately 1 ml of 0.9% sodium chloride solution to enhance contact of the test article with the dose site.
- Type of wrap if used: Gentle pressure was applied to the gauze to aid in the distribution of the test substance over the prepared site. The patch was
secured with non-irritating tape. The torso was wrapped with plastic in a semi-occlusive manner and secured with non-irritating tape which completely covered the plastic.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Residual test article was removed from the test site by gentle washing with lukewarm tap water at the end of the exposure period.
- Time after start of exposure: 4 hours.
SCORING SYSTEM:
The test sites were scored for dennal irritation at 30 to 60 minutes and 24, 48 and 72 hours after removal of wrappings. Erythema and edema were scored according to the numerical Draize technique below.
The skin was also evaluated for ulceration and necrosis or any evidence of tissue destmction. Additional signs were described.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0.11
- Max. score:
- 4
- Reversibility:
- fully reversible within: 3 days
- Remarks on result:
- other: Calculated on the basis of the scores at 24, 48, and 72 hours for ALL animals.
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0.11
- Max. score:
- 4
- Reversibility:
- fully reversible within: 3 days
- Remarks on result:
- other: Calculated on the basis of the scores at 24, 48, and 72 hours for ALL animals.
- Irritant / corrosive response data:
- Erythema and oedema, absent at 30 to 60 minutes after patch removal, were absent to very slight (in one male animal) at 24 and 48 hours and cleared by 72 hours.
There were no abnormal systemic signs noted during the observation period.
Body weight changes were normal. - Other effects:
- There were no signs of ill health or toxicity in any animal.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance is not classified as a skin irritant.
- Executive summary:
Objective:
To determine the potential of the test article to induce dermal imtation when administered demially to New Zealand White rabbits. The study is designed to comply with the standards set forth by:
-EPA - Primary Demnal Initation, 40 CFR 798.4470 (latest revision -1995)
-EC Official Joumal of the European Communities, L 383 A, Part B, Method B.4. Acute Toxicity (Skin Initation) 12/29/92
-OECD Guidelines for Testing of Chemicals, No. 404, Acute Dermal Irritation/Corrosion, adopted 7/17/92.
Method Synopsis:
Six healthy New Zealand White rabbits (3 males-3 females) were dosed dermaily with the test substance. The test article (0.5 g) was applied to one intact site/rabbit. The test article was kept in contact with the skin for 4 hours at which time the wrappings were removed. Dermal reactions were scored at 30 to 60 minutes and 24, 48 and 72 hours after removal of wrappings. Systemic signs were recorded at each observation period. Body weights were recorded pretest.
Summary:
Erythema and edema, absent at 30 to 60 minutes after patch removal, were absent to very slight at 24 and 48 hours and cleared by 72 hours.
There were no abnormal systemic signs noted during the observation period. Body weight changes were normal.
Conclusion:
The test substance is not classified as a skin irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.