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EC number: 283-483-2 | CAS number: 84650-03-3 A complex combination of hydrocarbons obtained by distillation of coal tar. It consists of aromatic and other hydrocarbons, phenolic compounds and aromatic nitrogen compounds and distills at the approximate range of 150°C to 210°C (302°F to 410°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15.3.-13.4.2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study was carried out in accordance with internationally valid GLP principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Distillates (coal tar), light oils
- EC Number:
- 283-483-2
- EC Name:
- Distillates (coal tar), light oils
- Cas Number:
- 84650-03-3
- Molecular formula:
- N/A
- IUPAC Name:
- Distillates (coal tar), light oils
- Details on test material:
- - Name of test material (as cited in study report): Carbolic oil
- Substance type: mixture of organic compounds
- Physical state: brown oil-like liquid
- Composition of test material, percentage of components: Main components (by GC) - Indene 17.27 % (w/w), Phenol 13.94 % (w/w), Indane 12.86 % (w/w), Naphthalene 10.54 % (w/w), m-Cresol 8.79 % (w/w), p-Cresol 4.87 % (w/w), o-Cresol 4.49 % (w/w), m-/p-Xylene 3.03 % (w/w), 1,3,5-Trimethylbenzene 1.52 % (w/w), 3-Ethyltoluene 1.41 % (w/w), Toluene 1.33 % (w/w), Ethylbenzene 1.18 % (w/w), 1,2,4-Trimethylbenzene 1.52 % (w/w), Coumarone 1.57 % (w/w), 28 other hydrocarbons from 0.1 up to 1.0 % (w/w), 14 other hydrocarbons up to 0.1 % (w/w)
- Lot/batch No.: Composite sample No. 3, ATE No. 10438
- Expiration date of the lot/batch: 08/2022
- Stability under test conditions: stable
- Storage condition of test material: The sample will be stored in supplied metal container in dry room at the temperature < 30°C.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: breeding farm VELAZ s.r.o., Koleč u Kladna, Czech Republic, RČH CZ 21760152
- Age at study initiation: 8-10 weeks at the time application
- Fasting period before study: about 20 hrs
- Housing: animal room with monitoring conditions – 3 animals of one sex in one plastic breeding cage. Because of repulsive smell of the test substance the animals were transferred to laminar box from on 3rd day after application – 3 animals of one sex in one plastic breeding cage.
- Diet (e.g. ad libitum): ST 1 BERGMAN – standard pelleted diet ad libitum
- Water (e.g. ad libitum): drinking tap water ad libitum
- Acclimation period: at least 5 day
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 + 3°C, permanently monitored
- Humidity (%): 30 – 70 %, permanently monitored
- Air changes (per hr): approximately 15 air changes per hour
- Photoperiod (hrs dark / hrs light): 12-hour light/12 hour dark
STUDY TIME SCHEDULE
Animal supply: 24. 02. 2010
Experimental part of study: 15. 03. - 13. 04. 2010
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Lot/batch no. (if required): 4726901
MAXIMUM DOSE VOLUME APPLIED: 2000 mg/kg bw
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: Testing schedule (according to EU Method B.1 tris Annex 1D)
START: 2000 mg/kg – 3 females (Step No.1): no deaths ► 2000 mg/kg – 3 females, (Step No. 2): death of one female ► END of study - Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 3 females per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations:
Body weight: before application, the 8th day and before euthanasia of animals
Mortality: daily
Clinical examination: daily
- Necropsy of survivors performed: yes (gross necropsy)
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- The test substance administered at the dose of 2000 mg/kg caused death of one female.
- Clinical signs:
- other: Clinical signs of intoxication (various changes) were observed in all six animals at the 1st and 2nd day after application. At the 3rd day after application no clinical signs of intoxication were observed in all surviving animals.
- Gross pathology:
- Pathologic macroscopic changes (Digestive tract - test substance in chymus; partial autolysis of organs) were observed in died female (No.6). Pathologic macroscopic changes (stomach - marked mucosal plicas; kidney – change of colour) were diagnosed during pathological examination in two animals.
- Other findings:
- - Histopathology:
Pathologic macroscopic changes (Digestive tract - test substance in chymus; partial autolysis of organs) were observed in died female (No.6). Histopathological examination of damaged organs was performed. Histopathological findings (liver – partial autolysis, centrolobular focal necrosis; stomach - partial autolysis; forestomach - partial autolysis; focal ulceration and focal polynuclear infiltration of mucous membrane) were observed.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- According to the study results the value of LD50 of the test substance, Carbolic Oil, (in female rats) is higher than 2000 mg/kg of body weight.
- Executive summary:
The test substance administered at the dose of 2000 mg/kg caused death of one female (No.6) in the group No.2 at the 3rd day morning after application.
Clinical signs of intoxication (various changes) were observed in all six animals at the 1st and 2nd day after application. At the 3rd day after application no clinical signs of intoxication were observed in all surviving animals.
Pathologic macroscopic changes (Digestive tract - test substance in chymus; partial autolysis of organs) were observed in died female (No.6). Histopathological examination of damaged organs was performed. Histopathological findings (liver – partial autolysis, centrolobular focal necrosis; stomach - partial autolysis; forestomach - partial autolysis; focal ulceration and focal polynuclear infiltration of mucous membrane) were observed.
Pathologic macroscopic changes (stomach - marked mucosal plicas; kidney – change of colour) were diagnosed during pathological examination in two animals.
According to the study results the value of LD50 of the test substance for female rats is higher than 2000 mg/kg of body weight.
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