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EC number: 203-403-1 | CAS number: 106-49-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions: No gross and/or microscopic pathology
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
- Reference Type:
- secondary source
- Title:
- p-Toluidine - CAS No: 106-49-0 - SIDS Initial Assessment Report.
- Author:
- OECD
- Year:
- 2 005
- Bibliographic source:
- UNEP Publications
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- Analytical purity not reported. Animal environmental conditions not reported. Fasting period not reported. Individual weights are not reported. Microscopic and gross pathology examination not performed.
- GLP compliance:
- no
- Remarks:
- GLP compliance was not mandatory at the time of the study
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- p-toluidine
- EC Number:
- 203-403-1
- EC Name:
- p-toluidine
- Cas Number:
- 106-49-0
- Molecular formula:
- C7H9N
- IUPAC Name:
- 4-methylaniline
- Details on test material:
- - Name of test material (as cited in study report): p-toluidine
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Germany
- Weight at study initiation: 160-180 kg
- Housing: 5 animals per cage
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Lutrol
- Doses:
- 100, 500, 600, 650, 700, 900 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- other: not applicable
- Details on study design:
- - Duration of observation period following administration: 14 days
- Other examinations performed: clinical signs - Statistics:
- Calculation of LD50 value: Fink, Arzneim.-Forschg: 15, 624, 1965
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 620 mg/kg bw
- 95% CL:
- >= 560 - <= 670
- Remarks on result:
- other: rats
- Mortality:
- see table 1
- Clinical signs:
- other: Signs of intoxication: poor reflexes, increased excretion of urine, emaciation, bloody eye, narcosis, cyanosis
Any other information on results incl. tables
Table 1: Overview of mortalities, time points of death and signs of intoxication:
dose (mg/kgbw) |
time o fdeaths |
number of deaths |
no of rats with signs of intoxication |
no of rats used |
100 |
no deaths |
0 |
10 |
10 |
500 |
2 -3 days |
2 |
10 |
10 |
600 |
3 hrs-5 days |
4 |
10 |
10 |
650 |
2 -3 hrs |
4 |
10 |
10 |
700 |
2 -3 days |
9 |
10 |
10 |
900 |
3 hrs- 3 days |
10 |
10 |
10 |
Applicant's summary and conclusion
- Executive summary:
To determine LD50 values of p-toluidine, an acute oral toxicity test was performed according to a method similar to OECD 401 with deviations (analytical purity not reported. Housing and feeding conditions not reported. Individual weights not reported. Microscopic and gross pathology examination not performed). In the present study 10 male rats per dose received dosages ranging from 100 mg/kg bw up to 900 mg/kg bw dissolved in lutrol. Signs of intoxications were hypoactivity, increase of urinary excretion, emaciation, bloody eyes, cyanosis, anorexia and narcosis which led to dose related death during the 14 day post exposure observation period. The resulting LD50 value is 620mg/kg bw (95%CL: 560 -670 mg/kg bw).
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